Abstract:To explore the effects of the combination of traditional Chinese and western medicine on the quality of life and mental health of patients with diabetes of deficiency of both qi and yin and its clinical significance. Methods:A total of 180 cases of Type II diabetes mellitus were admitted in Liaoning Province Hospital of TCM from July 2014 to May 2017 and were randomly divided into control group and combination of TCM and western medicine group with 90 cases in each group. Patients in the control group (group A) were treated with conventional western medicine. Patients in the combination group (group B) were treated with a formula of TCM based on conventional western medicine. The relevant laboratory test indicators and quality of life of patients with diabetes before and after treatment were scored and analyzed. Results:The quality of life, laboratory indexes, psychological anxiety and depression of the two groups were significantly improved (P<0.05), and the improvement of patients in the combination group were significantly better than those of the control group (P<0.05). Conclusion:The combination of traditional Chinese and western medicine has a good clinical value and effects in improving the clinical symptoms of patients with diabetes mellitus of deficiency of both qi and yin, improving the quality of life and reducing the incidence of depression and anxiety.