To observe the effect of different prescriptions on the antioxidant capacity of radiation. Methods:A total of 72 C57BL / 6J mice weighting (20±2)g, with 10 male and 10 female were obtained. Female rats and male rats were randomly divided into blank control group, radiation model group, radiation model+kidney detoxification group, with 12 in each group. Except the blank control group, the remaining mice were given 60CO γ-ray whole body irradiation, and absorbed dose were 5 Gy. Materials were taken on 1 d and 14 d after irradiation with 6 mice of each group each time. Then the head was cut, and the brain was removed from the ice plate. And the two sides of the hypothalamus were removed, and the tissue was homogenized to make 10% homogenate. By enzyme-linked immunosorbent assay (ELLSA), SOD MDA kit, in strict accordance with the instructions, the numerical SOD activity and MDA detection were observed in the hypothalamus of intracellular SOD and MDA levels, to analyse the effect of Chinese materia medica on the antioxidant capacity of radiation intervention. Results:The mice of SOD activity, with the radiation of 14 d radiation model group (110.26±5.50) and control group (127.34±4.38) had significant statistical difference (P<0.01). Bushen Jiedu Decoction group (130.98±4.55) and blank control group had statistically significant differences with the model group (P<0.01); Compared with 1 d (126.41±4.95, 120.05±7.17), the model group and Bushen Jiedu decoction group had significant statistical differences on 14 d after the radiation (P<0.01). For mice MDA value changes, there were significant differences in control group (6.99±1.85, 6.93±1.82), Bushen Jiedu Decoction group (9.82±0.70, 6.95±1.43) and model group (126.41±4.95, 17.88±3.39) at 1 d, 14 d after the radiation (P<0.01). Bushen Jiedu Decoction group, model group and blank control group have significant difference at 1 d after radiation (P<0.01). At 14 d after radiation, only the radiation model group had significant difference between blank control group (P<0.01); Bushen Jiedu Decoction group had significant difference between 14 d and 1 d after radiation (P<0.01).