To observe the clinical effects of electroacupuncture in schizophrenics with Hyperprolactinemia (HPRL) caused by the antipsychotic agents, and the effects of electroacupuncture on schizophrenics' psychiatric symptoms, so as to find out a simple, easy and suitable treatment plan in the grass-roots hospitals and the psychiatric hospitals. Methods:A total of 120 cases with schizophrenics with hyperprolactinemia who were admitted and treated in our hospital from January 2014 to June 2015, were randomly divided into treatment group and control group. Electroacupuncture was used in the treatment group while the placebo acupuncture in the control group. The level of the prolactin and the Positive and Negative Syndrome Scale (PANSS) scores before and after treatment were assessed. Results:After 2-week treatment, the level of the prolactin in the treatment group was decreased, and the difference was statistically significant (P<0.01), while not in the control group. There was a significant difference between the two groups in the lever of the prolactin after the treatment (P<0.01). Compared with before treatment, there was no difference in the PANSS scores between the two groups after the treatment (P>0.05). Electroacupuncture had a small influence on schizophrenics' psychiatric symptoms. Conclusion:Electroacupuncture has some effects on HPRL caused by the antipsychotic agents in schizophrenics. It can reduce adverse drug reactions in some degree and is worthy of promotion in grass-roots hospitals and the psychiatric hospitals.