Abstract:To evaluate contents of astragaloside in Huangqi Capsules measured by HPLC-ELSD. Methods:The octadecyl silane bonding silica gel was the filler, with acetonitrile-water (32:68) as mobile phase, and the detector was ELSD with the column pressure of 11.2~12.3 MPa and the flow rate of 1.0 mL/min. Column temperature: indoor temperature. Theoretical plate number was calculated by puerarin peak which should not be less than 4 000; Trailing factor was 1.02. Results:The method of HPLC-ELSD had good accuracy, repeatability, stability and recovery rate. A good linearity relationship of the sample size of asreagaloside comparison products in the range of 1.0528-10.528 μg (r=0.999 9, n=7). Conclusion:Contents of astragaloside in Huangqi Capsules measured by HPLC-ELSD is feasible.