To analyze the current situation and needs of the post-marketing clinical evaluation of Chinese patent medicine, summarize the existing problems, and discuss the principles and basic ideas of the overall design of the post-marketing clinical evaluation of Chinese patent medicine through the study of policy, market and academic research. Through overall design, to establish a middle-term and long-term development plan of the Chinese patent medicine, and to determine the research cycle, objectives and steps. The academic research, market development and funding can be integrated to promote secondary development of Chinese patent medicine efficiently with high quality. The overall design can promote utilization of the social resources effectively, further to improve the level and quality of the post-marketing clinical evaluation of Chinese patent medicine, providing recommendations and references to the post-marketing clinical evaluation of relevant products, and more importantly to promote post-marketing clinical evaluation more objective, scientific, feasible and credible.