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引用本文:邵培培，马丛，王北，谢幼红，张秦，张硕，顾文.养阴益气合剂联合硫酸羟氯喹治疗气阴两虚型干燥综合征36例临床观察[J].世界中医药,2018,(03):.

养阴益气合剂联合硫酸羟氯喹治疗气阴两虚型干燥综合征36例临床观察

Therapeutic Effects of Yangyin Yiqi Mixture Combined Hydoxychloroquine Sulfate on Sjgren's Syndrome with Qi and Yin Deficiency-A Clinical Observation on 36 Cases

投稿时间：2017-11-22

DOI：10.3969/j.issn.1673-7202.2018.03.017

中文关键词: 养阴益气合剂气阴两虚证原发性干燥综合征

English Keywords:Yangyin Yiqi mixture Qi and yin deficiency syndrome Primary Sjgren's syndrome

基金项目:北京市中医药薪火传承基金项目（2014-SZ-A-30）——王为兰名家研究室

作者	单位
邵培培，马丛，王北，谢幼红，张秦，张硕，顾文	首都医科大学附属北京中医医院风湿病科，北京，100010

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中文摘要:

目的：观察养阴益气合剂联合硫酸羟氯喹治疗气阴两虚型干燥综合征的临床疗效。方法：选取2015年1月至2016年12月首都医科大学附属北京中医医院收治的气阴两虚型干燥综合征患者70例，随机分为观察组（养阴益气合剂联合硫酸羟氯喹）36例和对照组（硫酸羟氯喹）34例，12周后比较2组患者的临床疗效和安全性。结果：观察组总有效率为805%，对照组总有效率为529%，2组比较有统计学意义（P<005）。2组治疗后口干、眼干、疲劳症状积分、唾液流率均较本组治疗前有改善（P<005），且观察组在改善口干、疲劳方面优于对照组（P<001）。2组治疗后动态红细胞沉降率、C反应蛋白、免疫球蛋白G水平均较治疗前下降（P<005），但2组间比较无统计学意义。结论：养阴益气合剂联合硫酸羟氯喹治疗气阴两虚型干燥综合征患者有效，较硫酸羟氯喹能更好地改善患者的口干及疲劳症状。

English Summary:

To observe the clinical efficacy of Yangyin Yiqi mixture combined with hydroxychloroquine sulfate in the treatment of Sjgren's syndrome of qi and yin deficiency type. Methods:Seventy cases of primary Sjgren's syndrome patients of qi and yin deficiency who were treated in our hospital from January 2015 to December 2016 were randomly divided into a treatment group (36 cases) and a control group (34 cases). The treatment group took Yangyin Yiqi mixture combined hydroxychlor sulfate, and the control group took hydoxychloroquine sulfate. After 12 weeks, the clinical efficacy and safety of the two groups were compared. Results:The total effective rate of the treatment group was 805%, and the total effective rate of the control group was 529%, There was statistical significance between the two groups (P<005). The scores of dry mouth, dry eye, fatigue symptom and saliva flow rate of the two groups after treatment were better than those before treatment (P<005). And the treatment group was better than the control group in improving dry mouth and fatigue (P<001). After treatment, the dynamic erythrocyte sedimentation rate, C reactive protein and immunoglobulin G levels in the two groups were decreased compared with before treatment (P<005)，But there was no statistical difference between the two groups. Conclusion:Effects of Yangyin Yiqi mixture combined with hydroxychloroquine sulfate in the treatment of Sjgren's syndrome with qi and yin deficiency are significant, which can better improve the symptoms of patients with dry mouth and fatigue compared with hydroxychloroquine sulfate.

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