世界中医药
文章摘要
引用本文:姬洪涛1,刘源2.大株红景天注射液对急性心肌梗死患者经皮冠状动脉介入治疗后炎性因子和左心功能的影响[J].世界中医药,2018,(03):.  
大株红景天注射液对急性心肌梗死患者经皮冠状动脉介入治疗后炎性因子和左心功能的影响
Effects of Sofren Injection on the Inflammatory Factor and Left Ventricular Function in the Treatment of Acute Myocardial Infarction Patients after Undergoing PCI
投稿时间:2017-08-21  
DOI:10.3969/j.issn.1673-7202.2018.03.022
中文关键词:  急性心肌梗死  经皮冠状动脉介入治疗  大株红景天注射液  炎性因子  左心功能  心肌损害  主要心脏不良事件  疗效
English Keywords:Acute myocardial infarction  Percutaneous coronary intervention  Sofren injection  Inflammatory factor  Left ventricular function  Myocardial damage  Major adverse cardiac events  Efficacy
基金项目:河南省科技厅科技攻关项目(172102310531)
作者单位
姬洪涛1,刘源2 1 河南省濮阳市安阳地区医院心内一科濮阳,455000 2 河南省郑州大学第一附属医院东院区心内三科郑州450052 
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中文摘要:
      目的:探究大株红景天注射液对急性心肌梗死(AMI)行经皮冠状动脉介入治疗(PCI)后患者的临床疗效,分析其对患者血清炎性因子及左心功能的影响。方法:选取2014年5月至2016年5月濮阳市安阳地区医院收治的AMI患者80例,所有患者均行PCI,术后将所有患者随机分为对照组及观察组,各40例。对照组给予常规治疗,观察组在对照组的基础上联合大株红景天注射液治疗,2周为1个疗程,2组均连续治疗2个疗程。治疗后统计2组临床疗效,比较治疗前后2组血清炎性因子水平的变化;于治疗前后采用彩色多普勒超声仪测定并比较2组左心功能指标的变化,记录2组治疗期间主要心脏不良事件(MACE)的发生情况。结果:治疗后观察组总有效率为775%,较对照组的550%显著升高(P<005);与治疗前比较,治疗后2组血清MPO、hs-CRP、IL-6、TNF-α等炎性因子水平及血清BNP、cTnT、CK-MB等心功能指标均显著降低(P<005),且观察组显著低于对照组(P<005);与治疗前比较,治疗后2组LVEDD及观察组LVESD均明显减小(P<005),且观察组小于对照组(P<005);治疗后2组LVEF及观察组FS均明显增大(P<005),且观察组大于对照组(P<005或P<001);随访期间观察组MACE发生率为300%,较对照组的550%显著降低(P<005)。结论:大株红景天注射液对AMI患者PCI后的临床疗效显著,可明显降低患者术后血清炎性因子,减轻患者心肌损害,提高左心功能,并可明显降低患者术后MACE的发生。
English Summary:
      To explore the clinical efficacy and the influence of Sofren injection on the inflammatory factor and left ventricular function in the treatment of acute myocardial infarction (AMI) patients after undergoing percutaneous coronary intervention (PCI). Methods:A total of 80 cases AMI patients who were treated with PCI in our hospital from May 2014 to May 2016 were elected and randomly divided into control group and observation group, with 40 cases were for each group. Control group were treated with conventional therapy, while observation group were treated combined with Sofren injection. Two weeks as one treatment course, both groups were treated continuously for 2 courses. The clinical efficacy of 2 groups after treatment was calculated, and the changes of serum inflammatory factors were detected and compared; the left ventricular function indexes of 2 groups by color doppler ultrasound instrument were measured and compared, and the major adverse cardiac events (MACE) in 2 groups during following-up were recorded. Results:The total effective rate of observation group (775%) was higher than control group (550%) significantly (P<005); Compared with before treatment, the levels of serum inflammatory factors of MPO, hs-CRP, IL-6, TNF-α and the levels of serum heart function indexes of BNP, cTnT, CK-MB in 2 groups decreased significantly after treatment (P<005 or P<001), and those of observation group were lower than that in control group (P<001); Compared with before treatment, the LVEDD of 2 groups and the LVESD of observation group decreased significantly after treatment (P<005 or P<001), and observation group was less than control group (P<005 or P<001); the LEVF of 2 groups and the FS of observation group increased significantly after treatment (P<001), and observation group was greater than control group (P<005 or P<001). The MACE occurrence rate of observation group was 300%, which decreased significantly compared with the 550% of control group during following-up (P<005). Conclusion:The clinical efficacy of Sofren injection is remarkable in the treatment of AMI patients after undergoing PCI, which can reduce the inflammatory factors levels, relieve the myocardial damage, improve left ventricular function and reduce the occurrence of MACE.
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