To observe the effects of Zishen Yutai Pill (ZYP) on pregnancy outcomes of women undergoing in vitro fertilization-embryo transfer. Methods:Infertile women underwent long protocol IVF cycle in our center from January 23, 2016 to September 11, 2015 were divided into drug group and placebo group randomly. ZYP or placebo was added from the day of down-regulation until 35 days after embryo transfer. Results:A total of 205 patients were included in this study. There was no difference in general between the drug group (103 cases) and placebo group (102 cases). During the process of COH, there was no significant difference in the time of stimulation (992 vs. 1006), the dosage of Gn, the endometrial thickness, the number of oocyte retrieval and the rate of top quality embryo between two groups. The E2 value per mature follicle, rates of implantation, rates of clinical pregnancy in drug group were higher in drug group than those in the placebo group under fresh ET (P<005). Conclusion:The application of ZYP could improve the quality of oocytes, promote embryo implantation and ultimately could improve the efficiency of IVF-ET.