世界中医药
文章摘要
引用本文:柏海燕,王婷,刘晓娟.滋肾育胎丸在体外受精-胚胎移植中效果的研究[J].世界中医药,2018,(03):.  
滋肾育胎丸在体外受精-胚胎移植中效果的研究
Study on Effects of Zishen Yutai Pill on Pregnancy Outcome of Women Undergoing in vitro Fertilization-embryo Transfer
投稿时间:2018-01-10  
DOI:10.3969/j.issn.1673-7202.2018.03.028
中文关键词:  滋肾育胎丸  不孕症  体外受精-胚胎移植  妊娠结局
English Keywords:Zishen Yutai Pill  Infertility  IVF-ET  Pregnancy outcome
基金项目:陕西省中医管理局面上研究课题(LCMS036)
作者单位
柏海燕,王婷,刘晓娟 西北妇女儿童医院生殖中心西安,710003 
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中文摘要:
      目的:探讨滋肾育胎丸对体外受精-胚胎移植(IVF-ET)结局的影响。方法:选取2016年1月23日至2016年9月11日西北妇女儿童医院生殖中心接受IVF-ET助孕的女性随机双盲分为滋肾育胎丸药物组及安慰剂组,均采用长方案,降调日起服药,至移植后35 d停药,比较2组超排卵的治疗过程及结局;结果:共入组205例,药物组(103例)和安慰剂组(102例)基础数据没有差异,2组促排卵时间、促排卵药物总量、HCG日子宫内膜厚度、优胚率亦没有统计学意义。药物组HCG日每成熟卵泡对应E2值、新鲜移植胚胎种植率及临床妊娠率均高于安慰剂组,差异有统计学意义(P<005);结论:IVF-ET过程中配合应用滋肾育胎丸能够改善卵细胞质量,促进胚胎种植,最终可提高IVF-ET助孕效率。
English Summary:
      To observe the effects of Zishen Yutai Pill (ZYP) on pregnancy outcomes of women undergoing in vitro fertilization-embryo transfer. Methods:Infertile women underwent long protocol IVF cycle in our center from January 23, 2016 to September 11, 2015 were divided into drug group and placebo group randomly. ZYP or placebo was added from the day of down-regulation until 35 days after embryo transfer. Results:A total of 205 patients were included in this study. There was no difference in general between the drug group (103 cases) and placebo group (102 cases). During the process of COH, there was no significant difference in the time of stimulation (992 vs. 1006), the dosage of Gn, the endometrial thickness, the number of oocyte retrieval and the rate of top quality embryo between two groups. The E2 value per mature follicle, rates of implantation, rates of clinical pregnancy in drug group were higher in drug group than those in the placebo group under fresh ET (P<005). Conclusion:The application of ZYP could improve the quality of oocytes, promote embryo implantation and ultimately could improve the efficiency of IVF-ET.
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