世界中医药

作者	单位
吴池华1，李一1，杨麟翰1，贾新建2	1 四川省医学科学院四川省人民医院乳腺外科，成都，610000； 2 四川省德阳市人民医院乳腺外科，德阳，618000

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中文摘要:

目的：探讨斑蝥胶囊对乳腺癌内分泌治疗患者生命质量的影响。方法：选取2015年5月至2017年6月四川省人民医院收治的乳腺癌根治术后患者126例为研究对象，以随机数字表法分为对照组63例，观察组63例，对照组给予内分泌药物治疗，观察组在对照组基础上加用纯中药制剂斑蝥胶囊治疗，观察2组患者治疗前后生命质量、免疫功能变化及治疗期间不良反应发生情况。结果：生命质量治疗前2组差异无统计学意义（P>005），经治疗后，观察组FACT-B、EORTC-QOL-C30评分与对照组比较，均显著较高，差异有统计学意义（P<005）；免疫功能治疗前2组患者差异无统计学意义（P>005），经治疗后，观察组CD8+与对照组比较，明显较低，CD4+、CD4+/CD8+与对照组比较，显著较高，差异有统计学意义（P<005）；观察组治疗期间恶心、潮热、肌肉关节疼痛及阴道流血发生率分别为1111%、794%、635%、317%，与对照组2540%、2063%、1905%、1429%比较，均明显较低，差异有统计学意义（P<005）。结论：在乳腺癌内分泌治疗中加入斑蝥胶囊，可有效提高患者免疫功能，减少不良反应，提高生命质量，值得推广。

English Summary:

To investigate the effects of Cantharidis Capsule on the quality of life of the patients with breast cancer endocrine therapy. Methods:A total of 126 patients who received radical mastectomy from May 2015 to June 2017 were selected as the subjects. They were randomly divided into 63 cases in the control group and 63 cases in the observation group. The control group was given endocrine drug treatment. The observation group was treated with pure Chinese medicine preparation of Cantharidin Capsule on the basis of the control group. The quality of life, immune function changes and adverse reactions during treatment were observed in the two groups before and after treatment. Results:There was no significant difference in the quality of life between the two groups before treatment (P > 005). After treatment, the scores of FACT-B and EORTC-QOL-C30 in the observation group were significantly higher than those in the control group. The difference was statistically significant (P<005). There was no significant difference between the two groups before treatment (P>005). After treatment, the CD8+ in the observation group was significantly lower than that in the control group, and CD4+ and CD4+/CD8+ were significantly higher than those in the control group. The difference was statistically significant (P<005). The incidence of nausea, fever, muscle joint pain and vaginal bleeding in the observation group were 1111%, 794%, 635% and 317%, respectively, which were significantly lower than those in the control group 2540%, 2063%, 1905% and 1429% (P<005). Conclusion:Adding Cantharidin capsule to endocrine therapy of breast cancer can effectively improve the immune function, reduce adverse reactions and improve the quality of life, and is worthy of promotion.

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