To study the therapeutic effect and dose-effect relationship of Raix Scutellariae decoction and Baicalin on hepatic fibrosis (HF) rats. Methods:HF rat model was established by subcutaneous injection of CCL4 for 8 weeks. Meanwhile, different doses of Raix Scutellariae decoction and Baicalin were administered. Histomorphology of liver tissue was observed. Liver HYP from hepatic tissue, the serum levels of ALT, AST, ALP, GGT, the liver and serum levels of SOD and MDA were detected by Kit. The liver fibrosis indexes including HA, PC-Ⅲ, C-Ⅳ and LN were measured by radioimmunoassay. Results:As compared with those in model group, the liver content of HYP, the serum levels of HA, LN, PCⅢ, the serum and liver levels of MDA, SOD were significantly changed in middle and low dose of Raix Scutellariae decoction and Baicalin groups, which also could significantly improve hepatic function. Additionally, the middle and low dosages were beneficial. However, the high dosage of Raix Scutellariae decoction could obviously aggravate liver injury. Conclusion:Middle and low dose of Raix Scutellariae decoction and Baicalin can effectively improve HF in rats and the action may be completed by antagonizing lipid peroxidation.