| To investigate the therapeutic effects of acupuncture on senile dementia and its influence on the metabolism of cytokines and blood lipids. Methods:A total of 96 cases of senile dementia admitted to the Third Affiliated Hospital of Southern Medical University, from September 2014 to March 2017 were randomly divided into the observation group (48 cases) and the control group (48 cases). The control group was treated with Donepezil Hydrochloride Tablets, and the observation group was treated with acupuncture on the basis of the control group. The two groups were treated for 3 months and therapeutic effects of the two groups were compared in terms of the scores of ADL, BEHAVE-AD, MMSE, cytokine and blood lipid metabolism before and after treatment. Results:The total effective rate of the observation group (8542%) was higher than that of the control group (6667%) (P<005). The ADL score and BEHAVE-AD score decreased in two groups after treatment while MMSE score increased (observation group: t=148483, 85707, 309352, the control group: t=85832, 42516, 166999, P<005). The ADL score of the observation group after treatment and BEHAVE-AD score were lower than the control group while the MMSE score was higher than the control group (t=66985, 44386, 168574, P<005). TNF-α and CRP and IL-6 levels decreased in two groups after treatment (observation group: t=191472, 145915, 288098, the control group: t=86531, 88128, 99875, P<005). TNF-α, CRP and IL-6 levels after treatment in the observation group were lower than that in the control group (t=113943, 169391, 209811, P<005). LDL-C, TG and TC levels decreased in two groups after treatment (observation group: t=153531, 243231, 130914, the control group: t=46533, 99162, 42570, P<005). LDL-C, TG and TC levels after treatment in the observation group were lower than those in the control group (t=132004, 144374, 106958, P<005). Conclusion:Acupuncture is effective in the treatment of Alzheimer's disease and can improve the cytokine and blood lipid metabolism in patients with Alzheimer's disease, and has important research value.