To explore the effects of acupuncture combined with immunosuppressor on the related antibodies and electromyogram index in the treatment of paraneoplastic syndrome patients. Methods:A total of 100 cases of paraneoplastic syndrome patients in our hospital from March 2015 to April 2017 were selected and randomly divided into control group and research group, with 50 cases in each group. Control group patients were treated with immunosuppressor for standardized treatment and research group patients were treated with TCM acupuncture differential treatment on the basis of control group. Patients in the 2 groups were treated for 4 weeks continuously. The clinical effects of 2 groups were statisticsed; the levels of serum related antibodies and the changes of electromyogram indexes of 2 groups before and after treatment were detected and compared. Results:The total effective rate of research group after treatment was 8600%, which was higher than 5600% of control group significantly (P<001); compared with before treatment, the serum anti-Hu antibody, anti-Yo antibody, anti-Ri antibody levels of 2 groups after treatment decreased significantly (P<001), and the levels of research group were lower than those of control group (P<001); compared with before treatment, the movement/sensory conduction velocity of median nerve and ulnar nerve of 2 groups before and after treatment quickened significantly (P<005 or P<001), and the velocity of research group was more quick than that in control group (P<001); the movement/sensory amplitude increased significantly (P<001), and amplitude in study group was greater than that in control group (P<001). Conclusion:Acupuncture combined with immunosuppressor can adjust the autoimmune disorders of paraneoplastic syndrome patients, which can improve the electromyogram of patients, recover normal nerve function, enhance the clinical efficacy effectively, and is better than use immunosuppressor alone.