To analyze the effectiveness and prognostic factors (platelet) of antithymus globulin (ATG)/antilymphocyte globulin (ALG) together with herbs of nourishing the kidney in treatment of severe aplastic anemia (SAA).Methods:A total of 151 cases with severe aplastic anemia who received ATG/ALG treatment in our hospital from January 1992 to May 2016 were analyzed retrospectively.They were treated mainly with nourishing herbs and combined with intense immunosuppression-ALG/ATG.And later cyclosporine A，male sex hormone and hemopoietic growth factor were used to treat severe aplastic anemia.Clinical efficacy，estimated survival rate were observed.Results:After one year follow up visit of 140 patients，the results showed 30 patients were basically cured (42.3%)，11 relieved (15.5%)，18 significantly improved (25.4%) and 12 invalid (16.9%).The overall effect ratio was 83.1%.The end time of observation was April 2016.The median observation period was 54 months (1-276 months)，and the overall survival rate was 83.6% at the end of the observation.The expected survival rates of 5 years and 10 years were 82.8% and 80.3% respectively.Finally，15 factors related to the efficacy were screened out.In addition，the coefficients (constants) were used to form the 4 equations for predicting the efficacy.The cross validation test showed that the accuracy of the equation was 83.8%.Conclusion:Nourishing the kidney Chinese herbs together with ATG/ALG in the treatment of SAA was valid and safe，which could also improve clinical curative effect and longer patients' survival rate.The curative effect prediction equation is simple in operation，easy to popularize in clinic，which can predict the curative effect in the early stage of treatment，and has high accuracy.It is a promising system to predict the effect and evaluate the prognosis.