| 引用本文:吴涛1，阿布都瓦哈甫·阿布拉2.乳岩汤联合GP化疗治疗晚期乳腺癌对免疫功能与血管内皮功能的影响[J].世界中医药,2018,(04):. |
|
| 乳岩汤联合GP化疗治疗晚期乳腺癌对免疫功能与血管内皮功能的影响 |
| Effect of Ruyan Decoction Combined with GP Chemotherapy in the Treatment of Advanced Breast Cancer on Immune Function and Vascular Endothelial Function |
| 投稿时间：2018-03-07 |
| DOI：10.3969/j.issn.1673-7202.2018.04.015 |
| 中文关键词: 晚期乳腺癌 乳岩汤 免疫功能 血管内皮功能 |
| English Keywords:Advanced breast cancer Ruyan decoction Immune function Vascular endothelial function |
| 基金项目:新疆维吾尔自治区自然科学基金（2011211A097） |
|
| 摘要点击次数: 804 |
| 全文下载次数: 799 |
| 中文摘要: |
| 目的：探讨乳岩汤联合GP化疗治疗晚期乳腺癌对免疫功能与血管内皮功能的影响。方法：选取2014年11月至2016年5月新疆医科大学附属中医医院收治的晚期乳腺癌患者70例，随机分为观察组和对照组，每组35例。对照组采用常规GP化疗，观察组在对照组的基础上加用乳岩汤治疗，21 d为1个疗程，2组均治疗3个疗程并定期随访1年。统计2组临床疗效及1年生存率；比较2组治疗前后T淋巴细胞亚群水平、血管内皮功能；统计分析2组治疗及随访期间不良反应发生情况。结果：治疗后观察组RR与1年生存率分别为74.29%、68.57%，显著高于对照组的51.43%、42.86%（P<0.05）；治疗后2组患者全血CD4+细胞百分率及CD4+/CD8+比值均较治疗前显著升高（P<0.01），且观察组显著高于对照组（P<0.05或P<0.01）；2组CD8+细胞百分率均较治疗前显著下降（P<0.01），且观察组显著低于对照组（P<0.05或P<0.01）；与治疗前比较，治疗后2组血清VEGF-A、VEGF-B、VEGF-C水平及全血CECs水平均显著下降，且观察组显著低于对照组（P<0.01）；观察组Ⅰ~Ⅱ级WBC及PLT下降的发生率均显著低于对照组（P<0.05）。结论：乳岩汤联合GP化疗治疗晚期乳腺癌可有效增强机体免疫功能，改善其血管内皮功能，提升疗效的同时降低化疗的不良反应，疗效显著优于常规GP化疗。 |
| English Summary: |
| To investigate the effect of ruyan decoction combined with GP chemotherapy in the treatment of advanced breast cancer on immune function and vascular endothelial function.Methods:A total of 70 patients with advanced breast cancer in our hospital from November 2014 to May 2016 were selected and randomly divided into observation group and control group，with 35 cases in each group.Control group was treated with GP chemotherapy，and observation group was treated with ruyan decoction on the basis of the control group.21 d as 1 cycle，2 groups were treated for 3 cycles and followed-up for 1 year.The clinical efficacy and 1 year survival rate were calculated; the levels of T lymphocyte subsets levels and vascular endothelial function before and after treatment of 2 groups were compared，and the toxicity in treatment and following-up period of 2 groups was statistically analyzed.Results:The RR and 1 year survival rate of observation group after treatment were 74.29%，68.57% respectively，which were significantly higher than the 74.29%，68.57% of control group respectively (P<0.05); After treatment，the blood cells percentage of CD4+ and CD4+/CD8+ ratio of 2 groups significantly increased than before treatment (P<0.01)，and observation group was significantly higher than those of control group (P<0.05 or P<0.01); the blood cells percentage of CD8+ of 2 groups decreased significantly，and observation group was significantly lower than that of control group (P<0.05 or P<0.01); compared with before treatment，the serum VEGF-A，VEGF-B，VEGF-C levels and CECs levels in whole blood of 2 groups after treatment significantly decreased，and observation group was significantly lower than control group (P<0.01); The incidence of Ⅰ~Ⅱ level WBC and PLT decline of observation group were significantly lower than control group (P<0.05).Conclusion:Ruyan decoction combined with GP chemotherapy in the treatment of advanced breast cancer can effectively enhance the body's immune function，improve the vascular endothelial function，enhance the curative effect，and reduce the toxicity of chemotherapy，and the curative effect is superior to that of conventional GP chemotherapy. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
