| 引用本文:解光辉1，张燕1，吕志峰2.加味温胆汤对老年冠心病PCI术后患者心肌纤维化和心功能的影响[J].世界中医药,2018,(04):. |
|
| 加味温胆汤对老年冠心病PCI术后患者心肌纤维化和心功能的影响 |
| Effect of Modified Wendan Decoction on Myocardial Fibrosis and Cardiac Function in Elderly Patients with Coronary Heart Disease after PCI |
| 投稿时间：2018-03-07 |
| DOI：10.3969/j.issn.1673-7202.2018.04.023 |
| 中文关键词: 冠心病 加味温胆汤 经皮冠状动脉介入术 心肌纤维化 心功能 |
| English Keywords:Coronary heart disease Modified Wendan decoction Percutaneous coronary intervention Myocardial fibrosis Cardiac function |
| 基金项目:河南省教育厅科技发展计划项目(172102310690) |
|
| 摘要点击次数: 864 |
| 全文下载次数: 792 |
| 中文摘要: |
| 目的:探讨加味温胆汤对老年冠心病经皮冠状动脉介入术(PCI)后患者心肌纤维化和心功能的影响。方法:选取2015年7月至2016年12月中国人民解放军第一五三中心医院收治的冠心病PCI术后老年患者135例,按照随机数字表法随机分为观察组(n=68)和对照组(n=67),2组均在PCI术后给予常规现代医学治疗,观察组在此基础上联合加味温胆汤治疗,2组均连续治疗6个月。比较2组临床治疗效果和心绞痛改善情况;检测并比较治疗前后2组心肌纤维化指标水平;比较治疗前后2组心功能指标水平。结果:治疗后对照组临床治疗总有效率为70.15%,显著低于观察组的88.24%(P<0.05);治疗3~6个月后2组SAQ评分均较治疗前显著升高,且观察组高于对照组(P<0.05);治疗3~6个月后2组PCⅠ、HA、PCⅢ及LN水平均较治疗前显著下降,且观察组低于对照组(P<0.05或P<0.01);治疗3~6个月后2组LVED均较治疗前显著减小,LVEF、CO和SV均较治疗前显著升高,2组间差异有统计学意义(P<0.05或P<0.01)。结论:加味温胆汤可降低老年冠心病PCI术后患者心肌纤维化程度,增强患者心功能,缓解PCI术后心绞痛,效果显著。 |
| English Summary: |
| To explore the effect of modified Wendan decoction on myocardial fibrosis and cardiac function in elderly patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods:A total of 135 cases of patients with coronary heart disease after PCI treated in our hospital from July 2015 to December 2016 were selected and randomly divided into the treatment group (n=68) and the control group (n=67).Both groups were given conventional western medicine treatment after PCI.The treatment group was treated with modified Wendan decoction on this basis of that.The 2 groups were treated continuously for 6 months.The clinical efficacy and the improvement of angina pectoris were compared between the 2 groups.The myocardial fibrosis and cardiac function indexes were detected and compared between the 2 groups before and after treatment.Results:After treatment，the total clinical effective rate was 70.15% of the control group，which was significantly lower than 88.24% of the treatment group (P<0.05); the SAQ scores of the 2 groups after 3~6 months treatment were significantly higher than those before treatment，and the treatment group was higher than the control group (P<0.05); the levels of PC I，HA，PC III and LN of the 2 groups after 3~6 months treatment were significantly lower than those before treatment，and the treatment group was lower than the control group (P<0.05 or P<0.01); LVED of the 2 groups after 3~6 months treatment significantly decreased，and LVEF，CO and SV were significantly higher than those before treatment.The difference between 2 groups was significant (P<0.05 or P<0.01).Conclusion:Modified Wendan decoction can reduce the degree of myocardial fibrosis in elderly patients with coronary heart disease after PCI，enhance the cardiac function and relieve the angina pectoris after PCI，and the efficacy is remarkable. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
