| 引用本文:王旺1，陆启滨2，任青玲2，杜明华2，史桂兰2.更年健肾汤治疗肝肾阴虚型绝经后骨质疏松症的临床效果[J].世界中医药,2018,(04):. |
|
| 更年健肾汤治疗肝肾阴虚型绝经后骨质疏松症的临床效果 |
| Clinical Observation on Gengnian Jianshen Decoction (GJD) in the Treatment of Postmenopausal Osteoporosis with Deficiency of Liver-yin and Kidney-yin Syndrome |
| 投稿时间：2017-10-11 |
| DOI：10.3969/j.issn.1673-7202.2018.04.026 |
| 中文关键词: 更年健肾汤 仙灵骨葆胶囊 绝经后骨质疏松症 肝肾阴虚证 骨密度 骨代谢 性激素 临床疗效 |
| English Keywords:Gengnian Jianshen Decoction Xianling Gubao capsule Postmenopausal osteoporosis Deficiency of liver-yin and kidney-yin syndrome Bone mineral density Bone metabolic markers Serum hormone Clinical effect |
| 基金项目:2015年江苏省中医院院级课题(Y15001) |
|
| 摘要点击次数: 900 |
| 全文下载次数: 750 |
| 中文摘要: |
| 目的：探讨更年健肾汤治疗肝肾阴虚型绝经后骨质疏松症患者的临床疗效。方法：选取2015年06月至2017年05月南京中医药大学附属医院诊治的肝肾阴虚型绝经后骨质疏松症患者60例，将其按照随机数字法随机分为观察组和对照组，2组均给予碳酸钙D3片，对照组加服仙灵骨葆胶囊，观察组加服更年健肾汤方剂，2组均以4周为1个疗程，连用4个疗程，观察2组治疗前及治疗后患者临床症状、骨密度指标（腰椎L2-4）、骨代谢指标［骨钙素（OC）、β-CTX］、性激素指标［雌二醇(E2)、卵泡刺激生成素(FSH)］，并对4个疗程治疗的临床疗效及治疗期间的不良反应进行评估。结果：治疗后观察组总有效率为93.33%，对照组的90.00%；观察组对改善烘热汗出、失眠多梦、口干咽燥等症状时疗效明显优于对照组，差异有统计学意义（P<0.05）；治疗后2组腰椎L2-4骨密度均较治疗前显著增加（均P<0.05）；治疗后2组E2较治疗前上升，观察组E2上升较对照组更为明显（P<0.05），2组FSH均较治疗后下降（P<0.05）；治疗后2组OC升高，β-CTX下降（P<0.05）。观察组无严重不良反应，对照组不良反应是胃脘胀痛及口苦咽痛。结论：采用更年健肾汤可以改善绝经后骨质疏松症的临床症状，同时可改善患者骨代谢和骨密度，临床疗效好，其作用机制可能是发挥类激素雌样作用，直接影响骨代谢水平。 |
| English Summary: |
| To investigate the clinical effects of Gengnian Jianshen Decoction (GJD) in the treatment of postmenopausal osteoporosis with deficiency of liver-yin and kidney-yin syndrome.Methods:A total of 60 cases of postmenopausal osteoporosis patients with deficiency of liver-yin and kidney-yin syndrome in Affiliated Hospital of Nanjing University of Chinese Medicine from June 2015 to May 2017 were chosen and randomly divided into the observation group and the control group.The two groups were given calcium carbonate D3，on basis of which the control group was given Xianling Gubao capsule，while the observation group was treated with GJD; All the two groups were treated for 4 months.The clinical symptoms，indexes including the bone mineral density (BMD) of lumbar L2-4，bone metabolic markers (osteocalcin (OC)，β-CTX)，and the levels of serum hormone (estradiol (E2)，and Follicle-Stimulating Hormone (FSH)) of two groups before and after treatment were observed.The curative effect and adverse reactions during the treatment course were evaluated.Results:After treatment，the total effective rate of the observation group was 93.33%，which was equivalent to 90% of the control group; The efficacy in improving symptoms of flushes and sweating，insomnia and dreaminess，dry mouth and throat of observation group was significantly better than the control group (P<0.05); After treatment，the BMD of the lumbar spine L2-4 in the two groups increased significantly (both P<0.01); E2 of both groups were higher than before treatment，which the observation group increased more obviously than the control group (P<0.05); FSH in the two groups were all lower than before treatment (both P<0.05); After treatment，OC of two groups were increased andβ-CTX decreased (both P<0.05).The routine blood and urine routine and heart，liver and kidney function in the two groups were all within the normal range，and the main adverse reaction was gastrointestinal reaction.The main adverse reactions of control group were epigastric pain and sore throat pain.Conclusions：Gengnian Jianshen Decoction in the treatment of postmenopausal osteoporosis can improve clinical symptoms，as well as the bone metabolism and bone density in patients，whose mechanism may be associated with the role of estrogen like hormone and direct impact on bone metabolism. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
