To investigate the effects of Buyang Huanwu Decoction combined with edaravone on hemorrheology and MMPs in patients with stroke. Methods:A total of 80 cases of stroke patients in our hospital were selected and randomly divided into observation group and control group according to random number table method, with 40 cases in each group. Patients in 2 groups were given conventional treatment. The control group was treated with intravenous infusion of edaravone, and observation group was treated with Buyang Huanwu Decoction based on that of the control group. All the patients were treated for 2 weeks. The clinical efficacy, hemorheology indexes and MMPs of patients in 2 groups before and after treatment were compared. Results:After treatment, the total effective rate of observation group was 95%, which was significantly higher than 77.50% in the control group (P<0.01); compared with the levels before treatment, the HS, LS, PV, Hct, and Fib of 2 groups decreased significantly after treatment (P<0.01), and observation group was significantly lower than those of control group (P<0.05 or P<0.01); compared with the levels before treatment, the serum MMP-2, MMP-9 levels of 2 groups after treatment decreased significantly, VEGF increased significantly, and there were significant differences between 2 groups (P<0.01). Conclusion:Buyang Huanwu Decoction combined with edaravone in the treatment of stroke can effectively regulate the disorder of hemorheology, reduce the level of MMPs and improve its vascular function, thereby inhibiting the progression of stroke, and the clinical efficacy is remarkable.