世界中医药

作者	单位
张历元1，李元文2，林欢儿3，蔡玲玲2，张玉婷1，李雪1，肖飞4	1 北京中医药大学，北京，100027； 2 北京中医药大学皮肤病研究所，北京，100027； 3 北京中医药大学深圳医院，深圳，518172； 4 健民集团儿童药物研究院,武汉,430052

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中文摘要:

冰片是中医外科要药之一，因具有良好的镇痛及透散、消肿效果被广泛用于各类疮疡的治疗。但其具体药性、毒性一直具有争议：1）因冰片商品种类繁多，来源复杂，而医家长期以来又对此认识不足；2）冰片根据配伍药物的不同对生物膜屏障作用不同，如配伍麝香与配伍葛根对血脑屏障有相反的影响；3）与缺乏严谨的毒理实验研究有关。通过梳理中药冰片的商品种类和现代药理研究进展可有效提升研究者对该药物的认识，从而更加严谨细腻地设计实验步骤并记录数据。

English Summary:

Borneol（Bingpian） is chemically named as 2-Camphanol, and its structure includes dextral,Levo borneol, and racemic borneol. Despite the abundant source of commodities, there are differences in efficacy and toxicity, due to the inclusion of impurity components. At present, the market is dominated by mechanochemical borneol, which contains many impurities. Generally considered that the quality of mechanochemical borneol is not as good as that of natural borneol. However, there are few comparative studies among different categories of borneol. Some studies have considered that the efficacy difference is not significant. Modern pharmacological studies have suggested that borneol at a concentration of 0.1% or less is safe, and does not cause damage to eye tissues. The use of borneol or combined with milkvetch root(Huangqi) can increase the permeability of the blood-brain barrier, and the compatibility of borneol and musk(Shexiang） can reduce the permeability of the blood-brain barrier, and protect the blood-brain barrier. Borneol has a double regulating effect on the excitability of the central nervous system, and it is characterized by low dose stimulation and high dose inhibition. However, previous researches have not detected the type and concentration of impurity components in the borneol, we need to conduct more experiments to get detailed data in the future.

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