世界中医药
文章摘要
引用本文:毕晋1,刘晓燕1,王志飞2,郭霞珍1.基于“四时五藏阴阳”理论探讨日食对大鼠和小鼠下丘脑单胺类神经递质分泌的影响[J].世界中医药,2018,(05):.  
基于“四时五藏阴阳”理论探讨日食对大鼠和小鼠下丘脑单胺类神经递质分泌的影响
Effect of Solar Eclipse on the Secretion of Monoamine Neurotransmitters in Rat's Hypothalamus
投稿时间:2018-04-15  
DOI:10.3969/j.issn.1673-7202.2018.05.004
中文关键词:  四时五藏阴阳  日食  天人相应  下丘脑  单胺类神经递质
English Keywords:Yin-yang of the four seasons and the five viscera  Eclipse  Correspondence betwen man and nature  Hypothalamus  Monoamine neurotransmitters
基金项目:国家自然科学基金面上项目(30472113;81573840)
作者单位
毕晋1,刘晓燕1,王志飞2,郭霞珍1 1 北京中医药大学北京100029 2 中国中医科学院中医临床基础医学研究所北京100700 
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中文摘要:
      目的:利用日全食这一特殊的自然条件,根据“四时五藏阴阳”理论,研究日食对大鼠和小鼠下丘脑单胺类神经递质分泌的影响。方法:在日食前、日食中以及日食后取大鼠和小鼠下丘脑组织。利用高效液相法测定大鼠和小鼠下丘脑中单胺类递质的含量。结果:与日食前组、日食中组比较,日食后组大鼠和小鼠下丘脑中5-HIAA含量显著减少(P<0.01),5-HT含量显著减少(P<0.01)。结论:单胺类神经递质对日食产生的光照等变化反应灵敏,在日食条件下,下丘脑的单胺类神经递质含量有显著性变化,说明中医学“四时五藏阴阳”和“天人相应”理论具有科学的内涵。
English Summary:
      To study the effects of changes in light conditions on the secretion of monoamine neurotransmitters in the hypothalamus of rats by using the special natural conditions of total solar eclipse according to the “yin-yang of the four seasons and the five viscera” theory. Methods:Rat hypothalamus was taken before, during, and after solar eclipse. The content of monoamine neurotransmitters in rat hypothalamus was determined by HPLC. Results:Compared with the pre-eclipse group and the eclipse group, the content of 5-HIAA in the hypothalamus decreased significantly (P<0.01), and 5-HT decreased significantly (P<0.01). Conclusion:Monoamine neurotransmitters are sensitive to changes in the light environment. Under light sudden changes, the monoamine neurotransmitter content of the hypothalamus has a significant change.
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