| 引用本文:韩俊阁1，杨宗纯2，张娜2，刘絮2，刘晓燕2，袁涛1，王效非1，王素梅1，郭霞珍2.对“四时五藏阴阳”理论生物学基础的探讨——时令季节对下丘脑-垂体-甲状腺轴功能节律的影响[J].世界中医药,2018,(05):. |
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| 对“四时五藏阴阳”理论生物学基础的探讨——时令季节对下丘脑-垂体-甲状腺轴功能节律的影响 |
| Discussion on Biological Basis of “Yin-yang of the Four Seasons and the Five Viscera”——Effects of Seasons on the Functional Rhythm of Hypothalamic-Pituitary-Thyroid Axis |
| 投稿时间：2018-04-15 |
| DOI：10.3969/j.issn.1673-7202.2018.05.007 |
| 中文关键词: 四时五藏阴阳 褪黑素 下丘脑-垂体-甲状腺 时令季节 肾应冬 |
| English Keywords:Yin-yang of the four seasons and the five viscera Melatonin Hypothalamus-pituitary-thyroid Seasons Kidney corresponding with winter |
| 基金项目:国家自然科学基金项目（81573840）；北京中医药薪火传承“3+3”工程程士德名家研究室 |
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| 中文摘要: |
| 目的：本研究观察了时令季节变化对下丘脑-垂体-甲状腺（HPT）轴功能的影响，以证实“四时五藏阴阳”理论的科学内涵。方法：检测了雄性金黄地鼠血浆中MT、TRH、TSH、T3、T4及甲状腺组织中MT、MR、T3、T4的含量。结果：发现血浆中MT、TRH、TSH、T3、T4含量呈现冬、春/秋高而夏至最低的变化趋势，甲状腺组织中MT、MR、T3、T4含量则呈现夏至最高而秋冬最低的变化趋势。结论：HPT轴的功能具有明显的季节相关性，在冬、春季节其机能相对增强，褪黑素可能为其季节性节律的调控因子，HPT轴的季节性功能变化为中医“四时五藏阴阳”理论提供了生物学依据。 |
| English Summary: |
| To systematically observe the effects of seasonal changes on the function of the hypothalamus-pituitary-thyroid (HPT) axis to verify the scientific connotation of the “yin-yang of the four seasons and the five viscera” theory. Methods:The contents of MT, TRH, TSH, T3, T4 in plasma and MT, MR, T3, and T4 in the thyroid tissue of male golden hamster were measured. Results:The results showed that the contents of MT, TRH, TSH, T3, and T4 in plasma showed the highest changes in winter, spring/autumn, and lowest in summer solstice. The contents of MT, MR, T3, and T4 in thyroid tissue showed the highest changes in summer solstice and lowest in autumn and winter. Conclusion:The function of HPT axis has obvious seasonal correlation, and its function is relatively enhanced in winter and spring. Melatonin may be a regulatory factor of this seasonal rhythm. The seasonal function change of HPT axis provides a biological basis for “yin-yang of the four seasons and the five viscera” theory. |
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