世界中医药

目的：探讨温通针法联合丹红注射液对血管性痴呆（VD）患者血清白细胞介素-18、干扰素-γ的影响。方法：选取2015年4月至2016年10月辽宁中医药大学附属医院收治VD患者132例，按照随机数表法分为对照组、温通组、丹红组及联合组，每组33例。对照组给予安慰剂，温通组给予温通针法治疗，丹红组给予丹红注射液治疗，联合组给予温通针法联合丹红注射液治疗。观察4组治疗前及治疗后（治疗6周）改良长谷川痴呆量表（HDS）评分变化，治疗前后血清白细胞介素-18、干扰素-γ水平变化，并进行统计学分析。结果：治疗后，对照组HDS评分及血清白细胞介素-18、干扰素-γ水平与治疗前差异无统计学意义（P>0.05）;温通组、丹红组及联合组HDS评分与治疗前比较，差异有统计学意义（P<0.05），且以联合组为最高，温通组、丹红组为其次，温通组、丹红组及联合组血清白细胞介素-18、干扰素-γ水平与治疗前比较显著降低（P<0.05），且均以丹红组为最高，丹红组次之，温通组为最低。相关性分析显示，温通组HDS评分与血清白细胞介素-18、干扰素-γ水平无明显相关性（P>0.05），丹红组HDS评分与血清白细胞介素-18、干扰素-γ水平呈负相关（P<0.05），丹红组HDS评分与血清白细胞介素-18、干扰素-γ水平呈负相关（P<0.05）。结论：温通针法联合丹红注射液治疗VD具有较好的效果，降低血清白细胞介素-18、干扰素-γ水平可能是其分子生物学机制之一。

English Summary:

To discuss the effects of WenTong needling combined with Danhong injection on serum of IL-18 and IFN-γ of patients with vascular dementia. Methods:A total of 132 patients with vascular dementia (VD) were selected from April 2015 to October 2016 in our hospitals, and randomly divided into control group, Wentong group, Danhong group, combination group according to the random number table method, with 33 cases in each group. The control group received placebo, and Wentong group received Wentong needling treatment. Danhong group received Danhong injection treatment, and combination group received Wentong needling combined with Danhong injection treatment. Changes in scores of revised Hasegawa dementia scale (HDS-R), serum levels of IL-18 and IFN-γ of all groups were observed before and after treatment, and statistical analysis was performed. Results:Afte treatment, score of HDS and serum of IL-18 and IFN-γin in control group was basically the same as compared with the conditions before treatment (P>0.05); Scores of HDS in Wentong group, Danhong group, combination group were significantly increased as compared with the conditions before treatment (P<0.05), and the highest was combination group, followed by the Wentong group and Danhong group; Serum of IL-18 and IFN-γin of Wentong group, Danhong group, combination group were significantly reduced as compared with the conditions before treatment (P<0.05), and the highest was Wentong group, followed by the Danhong group, and the lowest was combination group; Correlation analysis showed that score of HDS in the Wentong group was not correlated with serum of IL-18 and IFN-γ (P>0.05); Score of HDS in the Danhong group was negatively correlated with serum of IL-18 and IFN-γ (P>0.05); Score of HDS in the combination group was significantly negatively correlated with serum of IL-18 and IFN-γ (P>0.05). Conclusions: Wentong needling combined with Danhong injection treatment of VD has good effect, and lower levels of serum IL-18. IFN-γ is probably one of the molecular biology mechanism.

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