| 引用本文:王红兵，蒲志忠，邓彬，雷霄.康艾注射液对乳腺癌组织中PI3k/akt通路和CD、NK细胞的影响[J].世界中医药,2018,(05):. |
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| 康艾注射液对乳腺癌组织中PI3k/akt通路和CD、NK细胞的影响 |
| Effect of Kangai Injection on Expression of PI3k / akt in Breast Cancer Tissue and Its Effect on CD and NK Cells |
| 投稿时间：2017-10-25 |
| DOI：10.3969/j.issn.1673-7202.2018.05.026 |
| 中文关键词: 康艾注射液 乳腺癌 PI3k/akt 信号通路 CD NK细胞 免疫系统 分子生物学 |
| English Keywords:Kangai injection Breast cancer PI3k / akt Signal pathway CD NK Immune system Molecular biology |
| 基金项目:重庆市卫生局2011年医学科技计划项目（2011-1-138） |
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| 中文摘要: |
| 目的：观察康艾注射液在提高乳腺癌癌患者的临床疗效及其免疫力方面的机制，探讨其对PI3k/akt通路的影响。方法：选取2016年1月至2017年9月重庆市开州区人民医院收治的乳腺癌患者90例，采取随机数字表法分成对照组和观察组，各45例。2组均给予乳腺癌相关的基础治疗和化疗，观察组此基础上予以康艾注射液治疗，比较2组治疗的临床疗效、免疫指标、临床受益情况并分析对PI3k/akt通路的影响。结果：治疗后临床有效率观察组和对照组分别为86.23％，68.11％，差异有统计学意义（P<0.05）；治疗前2组免疫功能差异无统计学意义(P>0.05)，治疗后观察组免疫功能指标有提高，差异有统计学意义(P<0.05)，但对照组无明显改变，差异无统计学意义（P>0.05)；观察组临床受益情况（KPS和体重变化的稳定率和改善情况）均明显比对照组优，差异有统计学意义(P<0.05)；与治疗前比较，2组治疗后各时间节点的PI3K、pAKT、bcl水平均下降，差异有统计学意义(P<0.05)，而bax水平则升高，差异有统计学意义(P<0.05)，但是，各时间节点PI3K/AKT信号通路标志性蛋白水平的变化趋势，对照组比观察组更明显，差异有统计学意义（P<0.05）。结论:康艾注射液可明显改善乳腺癌患者疗效，是通过提高其免疫水平来实现，其中与PI3k/akt通路的介导有密切关联。 |
| English Summary: |
| To observe the mechanism of Kangai injection in improving the clinical efficacy and immunity of breast cancer patients, and to explore its effect on PI3k / akt pathway. Methods:From January 2016 to September 2017, 90 patients with breast cancer who were received by our department were divided into control group and observation group by random number table method, with 45 patients in each group. The two groups of patients were given breast cancer-related basic treatment and chemotherapy, and the observation group was added Kangai injection treatment. The clinical efficacy, immune indicators, clinical benefit and of PI3k / akt pathway of two groups were analyzed. Results:1)The clinical effective rates of the two groups were observation group 86.23% and control group 68.11% (P<0.05); 2)immune function indicators of the two groups before treatment were not comparable (P>0.05). 3)The clinical benefit (KPS and the stability and improvement of KPS) were observed in the observation group, and the difference was statistically significant (P<0.05). The level of PI3K, pAKT and bcl in the two groups were decreased at all time points after treatment (P<0.05), and the level of bax was increased (P<0.05). However, the trend of marker protein concentration of PI3K / AKT signal pathway was significantly higher in the control group than in the observation group (P<0.05). Conclusion:Kangai injection can significantly improve the efficacy of breast cancer patients, which is achieved by improving its immune level. And it is closely associated with PI3k / akt pathway. |
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