世界中医药

目的：探讨步长脑心通胶囊辅助治疗冠心病合并高血压患者的疗效及对内皮功能和血脂的影响。方法：选取2014年12月至2016年12月延安大学附属医院收治的冠心病合并高血压患者98例，根据随机表法分为观察组与对照组，每组49例。对照组口服硝苯地平缓释片，观察组在对照组基础上加步长脑心通胶囊辅助治疗。2组疗程均为8周。比较2组冠心病和高血压治疗疗效，治疗前后血管内皮功能和血脂变化。结果：观察组冠心病总有效率（93.88%）高于对照组（75.51%），差异有统计学意义（P<0.05）；观察组高血压总有效率（91.84%）高于对照组（71.43%），差异有统计学意义（P<0.05）；2组治疗后ET-1水平降低而NO水平增加（观察组t＝21.103、24.482，对照组t＝8.169、9.121，P<0.05）；观察组治疗后ET-1水平低于对照组而NO水平高于对照组（t＝11.783、11.740，P<0.05）；2组治疗后2组治疗后总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平降低而高密度脂蛋白胆固醇（HDL-C）水平增加（观察组t＝11.042、20.228、16.643、10.630，对照组t＝5.338、8.544、7.832、4.824，P<0.05）；观察组治疗后TC、TG、LDL-C水平低于对照组而HDL-C水平高于对照组（t＝6.821、11.449、9.823、6.450，P<0.05）。结论：步长脑心通胶囊辅助治疗冠心病合并高血压患者疗效显著，且能够改善血管内皮功能和血脂。

English Summary:

To explore the effect of Naoxintong Capsule on the treatment of coronary heart disease with hypertension and its effect on endothelial function and blood lipid. Methods:A total of 98 patients with coronary heart disease complicated with hypertension in our hospital from December 2014 to December 2016 were divided into observation group (n=49) and control group (n=49) according to the random number table method. The control group was treated with Extended Release Nifedipine Tablets, while the observation group was treated with Naoxintong Capsule on the basis of the control group. The two groups were treated for 8 weeks. The therapeutic effects of two groups of coronary heart disease and hypertension were compared. Results:The total efficiency of the observation group of coronary heart disease (93.88%) was higher than the control group (75.51%) (P<0.05); the total effective rate of the observation group of hypertension (91.84%) was higher than that of the control group (71.43%) (P<0.05); ET-1 level of the two group after treatment decreased and NO level increased (observation group t=21.103, 24.482, control group t=8.169, 9.121, P<0.05); after treatment, the level of ET-1 in observation group was lower than that in the control group and the level of NO was higher than that of control group (t=11.783, 11.740, P<0.05); TC, TG and LDL-C levels after treatment in the two groups decreased and HDL-C level increased (observation group t=11.042, 20.228, 16.643, 10.630, control group t=5.338, 8.544, 7.832, 4.824, P<0.05); TC, TG and LDL-C levels after treatment in the observation group were lower than that in the control group and the level of HDL-C was higher than that of control group (t=6.821, 11.449, 9.823, 6.450, P<0.05). Conclusion:The therapeutic effect of Naoxintong Capsule in the treatment of coronary heart disease with hypertension is significant, and it can improve the vascular endothelial function and blood lipid of patients with coronary heart disease.

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