To investigate the anti-inflammatory and analgesic effects of Lianwei Anaqi granules. Methods:The analgesic effect of Lianwei Anaqi granules was determined by hot plate test and acetic acid writhing test in mice. The anti-inflammatory effect of Lianwei Anaqi granules was observed by ear swelling test in mice. Mice were divided into 5 groups randomly, namely blank control group, Lianwei Anaqi granules at high, medium and low doses groups, and Aspirin group. The anti-inflammatory and analgesic effects of Lianwei Anaqi granules were observed after every group mice were orally given correspondence durg (ig) for 7 days. Results:Lianwei Anaqi granules could inhibit ear swelling caused by Xylene in mice markedly, and the high and medium doses of Lianwei Anaqi granules could increase pain threshold significantly. In the acetic acid writhing test and hot plate test, Lianwei Anaqi granules showed greater analgesic effects. Conclusion:Lianwei Anaqi granules have significant anti-inflammatory and analgesic effects.