| 引用本文:翟垚青1，闫文静2，乔志燕1.子午流注针法联合干扰素治疗对宫颈癌合并HPV感染患者T淋巴细胞亚群的影响[J].世界中医药,2018,(05):. |
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| 子午流注针法联合干扰素治疗对宫颈癌合并HPV感染患者T淋巴细胞亚群的影响 |
| Effect of Acupuncture Based on Midnight-noon Cycle of Qi in Combination with Interferon on T Lymphocyte Subsets in Patients with Cervical Cancer Co-infection of HPV |
| 投稿时间：2017-11-04 |
| DOI：10.3969/j.issn.1673-7202.2018.05.048 |
| 中文关键词: 宫颈癌 HPV感染 干扰素 子午流注针法 Th17 T淋巴细胞亚群 疗效 免疫抑制 |
| English Keywords:Cervical cancer HPV infection Interferon Acupuncture based on midnight-noon cycle of qi Th17 T lymphocyte subsets Efficacy Immunosuppression |
| 基金项目:河南省卫生厅2013年卫生政策研究课题计划(YWZY201306) |
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| 中文摘要: |
| 目的：探讨子午流注针法联合干扰素治疗对宫颈癌合并人乳头状瘤病毒（HPV）感染的临床疗效，并观察其对Th17细胞因子表达的影响。方法：选取宫颈癌合并HPV感染患者70例，随机分为对照组和观察组，每组35例。2组患者均接受紫杉醇+卡铂化疗方案以及重组人α-2β干扰素均匀涂宫颈表面，观察组在上述治疗方案的基础上加用子午流注针法联合治疗，比较2组治疗临床疗效、KPS评分、外周血Th17细胞百分比的变化，并观察不良反应发生情况。结果：治疗后2组KPS评分均较治疗前提高，其中观察组提高的趋势较对照组明显，差异有统计学意义（P<0.05）。观察组临床总有效率为74.29%，对照组临床总有效率42.86%，差异有统计学意义（χ2=3.29，P<0.05）。治疗后观察组有26例HPV转阴，转阴率74.29%,对照组12例转阴，转阴率34.29%，差异有统计学意义（χ2=2.83，P<0.05）。治疗后2组外周血Th17百分比均较治疗前下降，观察组较对照组下降更明显，差异有统计学意义（P<0.05）。结论：子午流注针法可改善宫颈癌合并HPV感染的免疫抑制状态，明显提高患者的生命质量。 |
| English Summary: |
| To investigate the clinical curative effect of the acupuncture based on midnight-noon cycle of qi in combination with interferon on cervical cancer co-infection of human papilloma virus (HPV), and to observe the effects on Th17 cytokines. Methods:A total of 70 cases of patients with cervical cancer co-infection of HPV in our hospital included into the study, and were randomly divided into the control group and the observation group, with 35 cases in each group. Two groups of patients accepted chemotherapy regimens of paclitaxel + carboplatin and recombinant human interferon α-2βevenly cervical surface, and the observation group combined with acupuncture based on midnight-noon cycle of qi on the basis of the above treatment. The clinical curative effect, Karnofsky Performance Status (KPS), peripheral blood Th17 cells percentage changes of two groups were compared, and the adverse reactions were observed. Results:1)KPS scores improved in the two groups after treatment, and the increase trend of observation group was more obviously than the control group. The differences were statistically significant (P<0.05). 2)The clinical total effective rate of observation group was 74.29%, and that was 42.86% in the control group. The differences were with statistically significant (χ2=3.29, P<0.05). After treatment, 26 cases of HPV turned to negative in the observation group, and the negative conversion ratio was 74.29%,.12 cases turned to negative in the control group, and the negative conversion ratio was 34.29%. The differences were statistically significant (χ2=2.83, P<0.05). 3)After a stage of treatment, peripheral blood Th17 percentage in the two groups decreased, and the observation group decreased more obvious than the control group. The differences were statistically significant (P<0.05). Conclusion:The acupuncture based on midnight-noon cycle of qi can improve the immunosuppression of cervical cancer co-infection of HPV, and can significantly improve the patient's quality of life. |
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