| 引用本文:董艳，王阶，姚魁武，姜文睿，张盈颖.《中华人民共和国药典》中成药治疗心悸的用药规律[J].世界中医药,2018,(05):. |
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| 《中华人民共和国药典》中成药治疗心悸的用药规律 |
| Analysis on the Chinese Patent Medicine for Palpitation in Pharmacopoeia of the People's Republic of China |
| 投稿时间：2017-09-28 |
| DOI：10.3969/j.issn.1673-7202.2018.05.057 |
| 中文关键词: 心悸 《中华人民共和国药典》 中成药 关联规则 熵聚类 用药规律 活血益气 补益肝肾 新处方 |
| English Keywords:Palpitation Pharmacopoeia of People's Republic of China Chinese patent medicine Association rules Entropy clustering Drug usage rules Promoting blood circulation and nourishing qi Nourishing liver and kidney New prescriptions |
| 基金项目:国家自然科学基金项目（81673847）——冠心病血瘀证相关lncRNA-miRNA调控网络研究；北京市科技计划课题（Z161100001816045）；国家中医药管理局中成药治疗优势病种临床应用指南标准化项目（SATCM-2015-BZ[402]） |
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| 中文摘要: |
| 目的：应用中医传承辅助平台，分析和总结《中华人民共和国药典》（2015年版）中成药治疗心悸的病症特征及组方规律，并由此探讨新的处方，为临床更好地治疗心悸提供新的思路和理论依据。方法：梳理《中华人民共和国药典》（2015年版）“成方制剂和单味制剂”中“功能与主治”出现“心悸”相关病症的所有中成药，运用中医传承辅助平台，建立方剂数据库，并应用该平台中集成的数据挖掘技术，整理心悸的病症特征、成方组成的用药规律及探索新方。结果：对治疗心悸的107个中成药和195味药物进行了分析，得出《中华人民共和国药典》中成药所治心悸的病症特征和这些药物的性味归经特征、用药频次及组方规律。心悸主要见于冠状动脉粥样硬化性心脏病、心律失常及高血压，主要证型为心血瘀阻证，其次是气阴两虚证和气滞血瘀证。治疗方面以益气、活血药频数最高且为关键药物，而主要的关联规则为远志->当归和远志->炒酸枣仁（置信度均为0.8）；通过分析进一步挖掘出18个核心药物组合，并探索出9个新处方。结论：通过中医传承辅助平台对《中华人民共和国药典》（2015年版）中治疗心悸的中成药进行数据分析，可明确心悸的病症特征及用药规律。该病最多见于冠心病心血瘀阻证，治疗以活血益气，补益肝肾为主。 |
| English Summary: |
| To analyze and summarize the composing principles of the Chinese patent medicines for palpitation collected in Pharmacopoeia of People's Republic of China (2015) through traditional Chinese medicine (TCM) inheritance system. Methods:The Chinese patent medicines used for palpitation in Pharmacopoeia were collected and input into the TCM inheritance system. The relationships between disease and symptom, composing principles and new prescriptions were explored and discovered. Results:The basic characteristic and composing principles from 107 Chinese patent medicines and 195 single herbs were analyzed. Palpitation was mainly seen in coronary heart disease, cardiac arrhythmias and hypertension. The most common syndrome was blood stasis, which was followed by qi and yin deficiency, qi and blood stasis. Therefore, herbs with function of nourishing qi and promoting blood circulation were key drugs and were in the highest frequency of usage. The main association rules were discovered to be Radix Polygalae->Radix Angelicae Sinensis and Radix Polygalae->Fried Semen Ziziphi Spinosae by setting the confidence parameter to 0.8. Moreover, 18 core drug combinations and 9 new prescriptions were explored. Conclusion:By TCM inheritance system, we explored and analyzed the Chinese patent medicines in Pharmacopoeia. Palpitation was mostly found in coronary heart disease and blood stasis syndrome. The managements of treatment were promoting blood circulation, nourishing qi, and nourishing liver and kidney. By applying statistical algorithm to the analysis of drug use in Chinese medicine, new ideas and theoretical basis for the treatment of palpitations could therefore be provided. |
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