世界中医药
文章摘要
引用本文:李陈1,2,常克2,杨静3,王玲4,肖飞4.紫草及紫草制剂的抗炎作用研究进展[J].世界中医药,2018,(06):.  
紫草及紫草制剂的抗炎作用研究进展
Research Progress of the Anti-inflammatory Effects of Radix Arnebiae and its Preparations
投稿时间:2018-05-10  
DOI:10.3969/j.issn.1673-7202.2018.06.013
中文关键词:  紫草  紫草素  紫草制剂  抗炎  进展
English Keywords:Radix Arnebiae  Shikonin  Radix Arnebiae preparations  Anti-inflammatory  Progress
基金项目:成都中医药大学横向科研项目(301-568)——健民复方紫草油药效及机理开发研究
作者单位
李陈1,2,常克2,杨静3,王玲4,肖飞4 1 四川省中西医结合医院儿科成都610041 2 成都中医药大学附属医院儿科成都610071 3 成都中医药大学成都610071 4 湖北省中药现代化工程技术研究中心武汉430052 
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中文摘要:
      目的:为紫草和紫草制剂的抗炎机制研究及产品开发提供参考。方法:以“紫草”“紫草素”“制剂”“抗炎”“进展”“zicao”“shikonin”“anti-inflammatory”等为关键词,在Pub Med、CNKI等多个数据库中查询建库至2017年12月31日的相关文献,对紫草、紫草素和紫草复方制剂抗炎作用的相关研究进行综述。结果与结论:共检索到相关文献128篇,其中有效文献41篇。紫草以新疆软紫草品质最佳,而滇紫草、泰山紫草等也被逐步肯定。紫草醇提物抗炎效果最优,紫草素及其衍生物的抗炎活性突出。紫草、紫草素及紫草复方制剂治疗烧烫伤、湿疹、银屑病、过敏性紫癜、关节炎、静脉炎、妇科炎症、急性肺损伤、重症急性胰腺炎伴肺损伤或肝损伤、局部脑缺血等多种疾病的实验研究正逐步深入,多认为其抗炎机制与NF-κB、IL-1β、IL-6、TNF-α、NO、CCR、COX-2、IL-22、IL-17等密切相关。紫草及紫草制剂现已广泛用于临床治疗湿疹、皮炎、妇科炎症、皮肤创面及黏膜损伤等多种炎症性疾病,其剂型多为油剂、膏剂、栓剂、喷雾剂等。如何高效发挥紫草及紫草制剂的抗炎作用,尚有待在微观层面运用生物组学技术等继续深入研究。
English Summary:
      To provide reference for the anti-inflammatory mechanism research of Radix Arnebiae and its preparations.Methods:Key words of “Radix Arnebiae”“shikonin”“preparation”“anti-inflammatory”“research progress” were used to search the relevant literature from the date of establishment of the database to December 31,2017 in PubMed and CNKI,and reviewed the research on anti-inflammatory action of Radix Arnebiae,shikonin and compound Radix Arnebiae preparations.Results: and Conclusion:128 related literatures were retrieved,41 of which were valid.Arnebia euchroma had the best efficacy,and Onosma paniculatum and Radix Arnebiae from Mount Tai were also gradually affirmed.The alcohol extract of Radix Arnebiae had optimal anti-inflammatory effect,and there were good anti-inflammatory activity of shikonin and shikonin derivatives.Experiment research of using Radix Arnebiae,shikonin and compound Radix Arnebiae preparations to treat burns,eczema,psoriasis,allergic purpura,arthritis,phlebitis,gynecological inflammation,acute lung injury,severe acute pancreatitis accompanied by lung injury or liver injury,local cerebral ischemia and other diseases were gradually thorough.Their anti-inflammatory mechanisms are closely related to NF-B,IL-1,IL-6,TNF-α,NO,CCR,cox-2,IL-22,and IL-17.Now Radix Arnebiae and compound Radix Arnebiae preparations,which dosage forms are mostly oil,ointments,suppositories and sprays,have been widely used in the clinical treatment of eczema,dermatitis,gynecological inflammation,skin wound and mucosal injury.How to develop the anti-inflammatory action of Radix Arnebiae and compound Radix Arnebiae preparations is remains to be further studied at the micro level by using bionomics technique.
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