To investigate the therapeutic effect of rhubarb chengqi decoction combine with ulinastatin on severe acute pancreatitis (SAP) and its influence on intestinal mucosal function and immune function of patients.Methods:A total of 128 patients with SAP who were treated in our hospital from January 2014 to June 2017 were selected,they were divided into observation group ( n=64 ) and control group ( n=64 ) according to random number table.The two groups were given conventional treatment of SAP and ulinastatin treatment,the observation group was given rhubarb chengqi decoction gastric tube injection,the control group was given physiological saline gastric tube injection treatment,the course of treatment was 2 weeks.The acute physiology and chronic health evaluation ( APACHE-II ),improvement time of systemic inflammatory response syndrome (SIRS),recovery time of intestinal function,Length of hospital stay,incidence of multiple organ failure (MODS) and mortality were observed.The intra-abdominal pressure,plasma two amine oxidase (DAO),plasma D-lactic acid,interleukin-6 ( IL-6 ),interleukin-8 ( IL-8 ),tumor necrosis factor-α ( TNF-α ),immunoglobulin IgM,IgA and IgG levels were compared between the two groups before and after treatment.Results:The improvement time of APACHE-II,SIRS,the recovery time of intestinal function and the length of stay in the observation group after treatment were significantly lower than those in the control group,the incidence of mortality and MODS were significantly lower than those of the control group ( P<0.05 ).After treatment,the intra-abdominal pressure,DAO and plasma lactic acid in the observation group were significantly lower than those in the control group ( P<0.05 ).After treatment,the serum levels of IL-6,IL-8 and TNF-α in the two groups were significantly decreased,and the observation group was significantly lower than that of the control group (P<0.05).After treatment,the serum levels of IgM,IgA and IgG in the observation group were significantly increased,and the levels of IgM,IgA and IgG in the control group were significantly decreased (P<0.05).The serum levels of IgM,IgA and IgG in the observation group were significantly higher than those in the control group ( P<0.05 ).Conclusion:Rhubarb chengqi decoction combine with ulinastatin in the treatment of SAP have good clinical curative effect,can effectively reduce the level of inflammatory factors,and enhancing immune function,which is worthy of clinical application.