To explore the effect of danggui ziyin on skin barrier function and hemorheology of patients with psoriasis vulgaris.Methods:A total of 114 cases of patients with psoriasis vulgaris in our hospital were selected as the research objects,and were randomly divided into the observation group and the control group,with each group for 57 cases.2 groups were given routine symptomatic treatment.The observation group was treated with the danggui ziyin on the basis of that,4 weeks for 1 course,and 2 groups were treated continuously for 2 courses.The clinical efficacy of 2 groups,the skin barrier function,serum inflammatory factors and hemorheological indexes before and after treatment were compared.Results:The total effective rates of the observation group and the control group were respectively 94.74%,80.70%.The observation group was significantly higher than the control group (P<0.05).Compared with those before treatment,the sebum content and cuticle moisture content of 2 groups significantly increased after treatment,and the observation group was significantly higher than the control group (P<0.01).The water loss through the epidermis significantly reduced,and the observation group was significantly lower than the control group (P<0.01).Compared with those before treatment,the serum IL-2,IL-8,IFN-γ levles of 2 groups after treatment significantly decreased,and the observation group was significantly lower than the control group (P<0.05 or P<0.01).The serum IL-4 level of 2 groups significantly increased,and the observation group was significantly higher than the control group (P<0.01).Compared those with before treatment,the high/medium/low shear whole blood viscosity,plasma viscosity and hematocrit of 2 groups after treatment significantly decreased (P<0.05 or P<0.01),and the observation group was significantly lower than the control group (P<0.01).Conclusion:Danggui ziyin can effectively improve skin barrier function of patients with psoriasis vulgaris,reduce the serum inflammatory factors levels,promote the hemorheology return to normal.And the clinical effect is better than conventional western medicine alone.