To study the effects of Shensong Yangxin Capsule combined with trimetazidine on cardiac function and related parameters of HRV in patients with chronic heart failure with sinus bradycardia.Methods:A total of 94 patients with chronic heart failure with sinus bradycardia in our hospital from July 2015 to August 2016 were selected.According to the visiting order,they were divided into observation group and control group (n=47).Control group patients were given trimetazidine for treatment,and the observation group on the basis of the control group was treated with Shensong Yangxin Capsule respectively.The clinical curative effect,heart function before and after the treatment,24 h dynamic electrocardiogram (ecg) average heart rate and related parameters of HRV changes of two groups were compared.Results:The total effective rate of observation group patients was 97.87% (46/47),which was significantly higher than that of control group 85.11% (40/47) (P<0.05).There was no significant difference in various cardiac function levels of two groups.After treatment,LVEF,CO and SV,6 min walking distance of observation group were (53.6±4.1) %,(5.0±0.7) L/min,(46.1±6.9) mL,(394.2±60.4) m/time respectively,which were significantly higher than that of control group (49.2±3.9) %,(4.2±0.6) L/min,(41.4±5.7) mL,(363.6±58.2) m/time (all P<0.05).24 h dynamic electrocardiogram average heart rate of the observation group and the control group after treatment were (66.8±6.1) times/min,(55.2±6.7) times/min respectively,which were significantly higher than before the treatment,and the observation group was significantly higher than the control group (P<0.05).SDANN,SDNN,rMSSD,PNN50 level of observation group after treatment were (112.6±20.1) ms,(129.2±21.5) ms,(25.2±5.7) ms,(6.0±0.8) %,ms respectively,which were significantly higher than that of control group (85.7±19.2) ms and (94.1±14.5) ms,(20.1±5.8) ms,(2.8±0.7) % (all P<0.05).Conclusion:The curative effect of Shensong Yangxin Capsule combined with trimetazidine in the treatment of chronic heart failure with sinus bradycardia is significantly,which can effectively improve cardiac function in patients as well as the related parameters of HRV,and promote patients recover at an early date. |