To study the curative effect of tonifying qi and resolving phlegm method on hypertension complicated with carotid artery plaque formation.Methods:A total of 62 patients with hypertension complicated with carotid artery plaque formation who treated in cardiovascular division of Guangzhou hospital during March, 2016 to March 2017, were divided into observation group and control group according to random number table method, with 31 cases in each group.The control group had amlodipine besylate tablets and/or irbesartanto control blood pressure, the atorvastatin calcium to regulate blood lipids; The observation group had tonifying qi and resolving phlegm method on the basic of blood pressure solution of the control group.Both of the two groups had continuous treatment for 3 months.The clinical symptoms and blood pressure conditions, proceed overall evaluation by using TCM syndrome scores of two groups were observed.Carotid artery color doppler examination was used to check carotid intima-middle thickness in the two groups before and after treatment.The serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol and apolipoprotein A1 and apolipoprotein B levels and serum osteopontin (OPN) of two groups of patients before and after treatment were detected.The contents of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase levels in the two groups before and after treatment were detected.Results:1) The total effective rate of observation group was 93.55% (29/31), and total effective rate of the control group was 70.96% (22/31).The differences were statistically significant (P<0.05).2) After treatment, carotid intima-middle thickness of the observation group was significantly less than control group (1.17±0.28 vs 1.43±0.26 mm), and the differences were statistically significant (P<0.05).The plaque area of observation group was significantly smaller than that of the control group (3.12±0.73 vs 3.94±0.96 cm2) after treatment, and the differences were statistically significant (P<0.05).3) In the observation group after treatment, serum TC (4.29±1.52 vs 5.37±0.87 mmol/L), TG (1.74±0.43 vs 2.65±0.68 mmol/L) and LDL (1.65±0.89 vs 2.87±1.12 mmol/L) levels were lower than the control group, and the differences were statistically significant (P<0.05).In the observation group after treatment, serum levels of HDL (1.94±0.41 vs 1.23±0.38 mmol/L) were higher than that of control group, and the differences were statistically significant (P<0.05).4) After the course of treatment, peripheral blood concentrations of OPN reduced in both of the two groups, and the observation group were superior to that of control group (P<0.05).Conclusion:Tonifying qi and resolving phlegm method can significantly improve clinical syndrome of patients with hypertension complicated with carotid artery plaque, not only can inhibit carotid intima-middle thickening, but also can inhibit lipid plaque formation and protect carotid artery from damage by reducing the levels of TC, TG, LDL and OPN and raising the HDL levels.