世界中医药
文章摘要
引用本文:杜家豪,金军,吴衍伟.小柴胡汤辅助化疗对乳腺癌免疫功能及生命质量的影响[J].世界中医药,2018,(06):.  
小柴胡汤辅助化疗对乳腺癌免疫功能及生命质量的影响
Effect of Xiaochaihu Decoction Combined with Chemotherapy on Immune Function and Quality of Life of Breast Cancer
投稿时间:2018-01-26  
DOI:10.3969/j.issn.1673-7202.2018.06.035
中文关键词:  乳腺癌  化疗  小柴胡汤  临床疗效  生命质量  肿瘤标志物  免疫指标  不良反应
English Keywords:Breast cancer  Chemotherapy  Xiaochaihu Decoction  Clinical efficacy  Quality of life  Tumor markers  Immune index  Adverse reaction
基金项目:佛山市医学类科技攻关项目(0009380120318053)
作者单位
杜家豪,金军,吴衍伟 广州中医药大学附属广东中西医结合医院肿瘤科,佛山,528200 
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中文摘要:
      目的:评价小柴胡汤辅助化疗对乳腺癌患者的疗效,同时观察其对免疫功能的影响。方法:选取2013年02月至2016年11月广州中医药大学附属广东中西医结合医院收治的乳腺癌晚期患者60例纳入研究,根据治疗方法分为对照组和观察组,其中对照组患者32例接受单纯静脉药物化疗,观察组患者28例接受静脉化疗药物治疗的同时口服小柴胡汤加减,治疗周期均为3个月,比较治疗前后2组患者生命质量评分、临床症状改善率、广谱肿瘤标志物(CEA、CA153、CA125)含量、免疫指标变化(CD3+、CD4+、CD8+、CD4+/CD8+、IgG、IgA、IgM)以及不良反应发生率的变化。结果:1)2组患者治疗后生命质量评分均有所提升,其中观察组优于对照组(P<0.05);2)观察组临床总有效率60.71%,与对照组31.25%比较,差异有统计学意义(P<0.05);3)2组患者治疗后CEA、CA153、CA125浓度均明显下降,与治疗前比较,差异有统计学意义(P<0.05),且观察组优于对照组(P<0.05);4)治疗后观察组外周血CD3+、CD4+、CD4+/CD8+、IgG、IgA、IgM水平均高于对照组,CD8+低于对照组,差异均有统计学意义(P<0.05);5)2组不良反应均以恶心呕吐、头痛头晕、肾损害、白细胞下降、脱发及心脏毒性为主,其中观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:小柴胡汤可通过增强乳腺癌患者的免疫能力而提高临床疗效,优化生命质量。
English Summary:
      To evaluate the effect of Xiaochaihu Decoction combined with chemotherapy on breast cancer and to observe its effects on immune function. Methods:A total of 60 cases with advanced breast cancer were included in the study. The patients were divided into control group and observation group. 32 cases in control group received intravenous chemotherapy, and 28 cases in the observation group received intravenous chemotherapy drug treatment and oral administration of Xiaochaihu Decoction. The treatment period was 3 months. Symptoms in two groups before and after treatment, the scores of quality of life, improvement rate of tumor markers (CEA, CA153, CA125), the content changes of immune indexes (CD3+, CD4+, CD8+, CD4+/CD8+, IgG, IgA, IgM) change rate and adverse reaction were compared. Results:Quality of life scores improved in the two groups of patients after treatment, and the observation group was better than the control group (P<0.05); the total efficiency of observation group was 60.71%, and had significant difference when compared with 31.25% in the control group (P<0.05); after treatment, CEA, CA153, CA125 concentrations of two groups were significantly decreased, and there was statistically significant (P<0.05) compared with before treatment. The observation group was better than the control group (P<0.05); after treatment, peripheral blood CD3+, CD4+, CD4+/CD8+, IgG, IgA and IgM levels of the observation group were higher than the control group, and CD8+ level was lower than the control group. The differences were statistically significant (P<0.05); The adverse reactions were nausea and vomiting, headache and dizziness, renal damage, leukopenia, alopecia and cardiac toxicity, and the adverse reaction rate of the observation group was lower than in the control group. The difference was statistically significant (P<0.05). Conclusion:Xiaochaihu Decoction can improve the clinical curative effect and optimize the quality of life by enhancing the immune ability of the breast cancer patients.
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