To investigate the clinical effect of the treatment of middle and late stage hepatocellular carcinoma by the method of replenishing qi and nourishing yin combined with hepatic artery chemoembolization (TACE).Methods:A total of 92 cases of middle and advanced stage hepatocellular carcinoma treated in the Department of Intervention of the First Hospital Affiliated with Hebei Northern University from March 2013 to March 2016 were selected.The patients were randomly divided into observation group (n=46) and control group (n=46) according to random table method.The control group was treated with TACE,and the observation group was treated combined with the method of replenishing qi and nourishing yin.After two weeks of treatment,the clinical curative effect,quality of life,liver function index,blood routine and the incidence of adverse reactions were observed.Results:The efficiency of observation group (89.13 %) was significantly higher than that of control group (76.09 %) (P<0.05).There was no significant difference between the observation group and the control group in TBil,AST,ALT,RBC,WBC and PLT (P>0.05).TBil,AST,ALT,RBC,WBC and PLT of the two groups were improved after treatment (P<0.05).The observation group was superior to the control group (P<0.05) in the improvement of Ttil,AST,ALT,RBC,WBC and PLT.The improvement of quality of life in the observation group was significantly better than that in the control group (P<0.05).The incidence of adverse reactions in the observed group was significantly better than that in the control group (P<0.05).Conclusion:Replenishing qi and nourishing yin method combined with TACE in treating patients with middle-and advanced stage hepatocellular carcinoma can significantly improve the clinical efficacy,liver function and quality of life,and the incidence of adverse reactions is better than that of simple TACE,which is worthy of clinical promotion.