| 引用本文:郑忻1，曲妮妮1，马丽佳1，秦一冰2，徐欣2.苏子降气汤对慢性阻塞性肺疾病急性发作期（痰浊壅肺证）肺功能的影响及部分机制[J].世界中医药,2018,(06):. |
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| 苏子降气汤对慢性阻塞性肺疾病急性发作期（痰浊壅肺证）肺功能的影响及部分机制 |
| Study on Effects and Part Mechanism of Suzi Jiangqi Decoction on Lung Function of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Turbid Phlegm Obstructing Lung Syndrome |
| 投稿时间：2018-01-31 |
| DOI：10.3969/j.issn.1673-7202.2018.06.044 |
| 中文关键词: 苏子降气汤 痰浊壅肺证 慢性阻塞性肺疾病 肺功能 生命质量 白细胞介素-21 趋化因子13 |
| English Keywords:Suzi Jiangqi Decoction Syndrome of turbid phlegm obstructing lung Chronic obstructive pulmonary disease Pulmonary function Quality of life Serum interleukin-21 CXCL13 Mechanism research |
| 基金项目:辽宁省科学事业公益研究基金(2014001012) |
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| 中文摘要: |
| 目的：观察苏子降气汤对慢性阻塞性肺疾病急性发作期（痰浊壅肺证）患者肺功能和生命质量的影响，并探讨其部分机制。方法：选取2015年1月至2017年5月辽宁中医药大学附属医院呼吸内科住院的AECOPD（痰浊壅肺证）患者共108例，通过随机数字表法将108例患者按照随机编号分成对照组与观察组，每组54例；观察组：在对照组西药治疗的基础上根据中医辨证论治予苏子降气汤口服。根据量化的中医证候评分变化、肺功能和生命质量观察苏子降气汤对AECOPD（痰浊壅肺证）的影响，并采用酶联免疫吸附试验（ELISA）法检测IL-21和CXCL13的水平。结果：与治疗前比较，2组中医证候评分明显降低（P<0.05），且观察组治疗后的中医证候评分明显低于对照组（P<0.05）。治疗后2组肺功能均较治疗前有所提高，然而观察组肺功能的主要指标FVC(L)、FEV1(L)、FEV1/FVC(%)和PEF(L/s)明显优于对照组（P<0.05）。治疗后观察组生命质量评定症状、活动、影响和平均分均显著低于对照组（P<0.05）。治疗后IL-21和CXCL13的表达水平2组均明显下降（P<0.05），且观察组优于对照组（P<0.05）。结论：苏子降气汤可明显改善AECOPD（痰浊壅肺证）患者的病情，提高患者的肺功能及生命质量，其作用机制可能与降低外周血IL-21及CXCL13水平有关。 |
| English Summary: |
| To observe the effect of Suzi Jiangqi Decoction on pulmonary function and quality of life of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore its mechanism.Methods:A total of 108 cases of patients with AECOPD with turbid phlegm obstructing lung syndrome in our hospital from January 2015 to May 2017 were selected and randomly divided into control group and observation group according to random number table method, with 54 cases in each group; The observation group：on the basis of Western medicine treatment in the control group, given oral administration of Suzi Jiangqi Decoction based on syndrome differentiation.According to the lung function and life quality of TCM syndrome score changes, the effect of Suzi Jiangqi Decoction on phlegm obstructing lung type AECOPD was observed, and enzyme linked immunosorbent assay (ELISA) method was used to detect IL-21 and CXCL13 levels.Results:Compared with those before treatment, the TCM syndrome scores of two groups were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than that in the control group after treatment (P<0.05).After treatment, the lung function of the two groups increased compared with that before treatment.However, the main indicators of lung function in the observation group FVC (L), FEV1 (L), FEV1/FVC (%) and PEF (L/s) were significantly better than those in the control group (P<0.05).After treatment, the symptom, activity, influence and average score of quality of life in the observation group were significantly lower than that of the control group (P<0.05).After treatment, the expression level of IL-21 and CXCL13 in the 2 groups was significantly decreased (P<0.05), and the observation group was better than the control group (P<0.05).Conclusion:Suzi Jiangqi Decoction can obviously improve the phlegm obstructing lung type AECOPD disease, improve lung function and life quality of the patients, and the mechanism may be related to the decrease of peripheral blood IL-21 and CXCL13 concentration. |
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