世界中医药
文章摘要
引用本文:皮园园,张先杰,姜涛.清胰汤治疗急性胰腺炎随机对照试验的Meta分析[J].世界中医药,2018,(06):.  
清胰汤治疗急性胰腺炎随机对照试验的Meta分析
Meta-analysis of Randomized Controlled Trials of Qingyi Decoction in Treatment of Acute Pancreatitis
投稿时间:2017-05-02  
DOI:10.3969/j.issn.1673-7202.2018.06.057
中文关键词:  清胰汤  常规西医治疗  随机对照试验  Meta分析  有效率  病死率  住院时间  敏感分析  发表偏倚
English Keywords:Qingyi Decoction  Conventional western medicine  Randomized controlled trials  Meta-analysis
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作者单位
皮园园,张先杰,姜涛 北京中医药大学东直门医院普外科,北京,100700 
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中文摘要:
      目的:客观评价清胰汤联合常规西医治疗急性胰腺炎的有效应和安全性。方法:计算机检索PubMed、Embase、Cochrane Library、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方(WanFang)和维普(VIP)数据库,手工补充检索相关的重要会议集和过刊资料,由2名研究者单独筛选文献、提取资料。用软件RevMan5.3和stata14作Meta分析。结果:共纳入的37篇RCTs,共纳入3 165例急性胰腺炎患者。Meta分析结果:1)清胰汤联合常规西医治疗急性清胰汤在提高有效率方面优于单纯使用西医常规治疗(RR=1.13,95%CI[1.09,1.17],Z=6.59,P<0.00001);2)清胰汤联合常规西医治疗能够明显降低急性胰腺炎患者的病死率和住院时间(RR=0.36,95%CI[0.24,0.53],P<0.00001;MD=-5.52,95%CI[-6.20,-4.84],Z=15.93,P<0.00001);3)平均住院时间的亚组SAP的合并效应量MDSAP=-5.99,亚组MAP的合并效应量MDMAP=-5.05,MDSAP>MDMAP,因此清胰汤联合常规西医治疗在缩短住院时间方面对重症胰腺炎患者的效果更明显。结论:基于目前的证据,清胰汤联合常规西医治疗急性胰腺炎能够明显提高有效率,降低病死率,缩短住院时间,且对重症急性胰腺炎的效果更佳,但需要更多高质量的证据进一步验证本结论。
English Summary:
      To evaluate the efficacy and safety of Qingyi Decoction combined with conventional western medicine in the treatment of acute pancreatitis.Methods:We searched PubMed,Embase,Cochrane Library,CBM,CNKI,WanFang) and VIP database,Manual Supplement retrieval important meeting set and Backissues related,by 2 researchers independently screened literature extracted data.Meta analysis with software RevMan5.3 and stata14.Results:A total of 37 RCTs were included in the study,including a total of 3165 patients with acute pancreatitis.Meta analysis results:1)Qingyi Decoction Combined with conventional western medicine in the treatment of acute Qingyi Decoction in improving the efficiency is better than the simple use of conventional western medicine treatment (RR=1.13,95%CI[1.09,1.17],Z=6.59,P<0.00001).2)the QingYi Decoction Combined with routine western medicine treatment can significantly reduce the mortality of patients with acute pancreatitis and the rate of hospitalization time (RR=0.36.95%CI[0.24,0.53],P<0.00001;MD=-5.52,95%CI[-6.20,-4.84],Z=15.93,P<0.00001).3)the combined effect of the amount of MDSAP=-5.99 subgroup SAP the average hospitalization time,the combined effect of the amount of MDMAP=-5.05 subgroup MAP,MDSAP>MDMAP,so Qingyi decoction combined with conventional western medicine in the treatment of severe acute pancreatitis and shorten the hospitalization time with the more obvious effect.Conclusion:Based on current evidence,Qingyi Decoction Combined with conventional western medicine in the treatment of acute pancreatitis can significantly improve the efficiency,reduce the mortality,shorten the hospitalization time,and better effect on severe acute pancreatitis,but need more high quality evidence to further validate this conclusion.
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