| 引用本文:袁玉亮1，朱瑞丽1，孙士鹏1，魏华民2.苓桂剂调节固有免疫治疗青春期寻常型痤疮[J].世界中医药,2018,(07):. |
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| 苓桂剂调节固有免疫治疗青春期寻常型痤疮 |
| Effects of Linggui Prescription on Adolescent Acne Vulgaris Through Innate Immunity Regulation |
| 投稿时间：2018-02-26 |
| DOI：10.3969/j.issn.1673-7202.2018.07.012 |
| 中文关键词: 青年期寻常型痤疮 苓桂剂 Toll样受体 固有免疫调节 |
| English Keywords:Adolescent acne vulgaris Linggui Prescription Toll-like receptor Innate immunity regulation |
| 基金项目:国家自然科学基金青年基金项目(81704092)——从角质形成细胞K17/抗凋亡基因表达探讨银屑病血热证/血瘀证型特点的分子机制;大兴区公共服务领域人才培养资金支持;大兴区优秀中青年医务工作者资助 |
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| 中文摘要: |
| 目的:观察苓桂剂治疗青春期寻常型痤疮的临床疗效,并从免疫调节方面探讨其可能的机制。方法:选取2016年3月至2017年11月中国中医科学院广安门医院南区收治的青年期寻常型痤疮患者62例作为观察组以及同时期健康志愿者20例作为对照组,苓桂剂治疗10 d后评估临床有效率并用流式细胞仪分析治疗前后患者外周血的CD14+TLR2+及ELISA法检测IL-4、IL-8、TNF-α和COX2水平。结果:所有患者均不同程度缓解,CD14+TLR+在正常组、治疗前、治疗后分别为为(78±5)%、(92.3±6.7)%、(81.2±4.6)%,治疗后较治疗前下降明显(P=0.044),IL-4、IL-8、TNF-α和COX2水平治疗后亦显著下降(P<0.05)。结论:苓桂剂可能通过调节固有免疫途径改善青春期寻常型痤疮。 |
| English Summary: |
| To observe the clinical effects of Linggui prescription on adolescent acne vulgaris, and investigate the possible mechanism of it on immune regulation. Methods:Sixty-two cases of adolescent acne vulgaris and 20 healthy cases were involved in the study. After 10 days of Chinese herbal treatment, clinical efficient was evaluated, and also rate of CD14+TLR2+ and level of IL-4, IL-8, TNF-α and COX2 were detected in peripheral blood by Flow Cytometer and ELISA. Results:All cases had a clinical remission in different degree, rate of CD14+TLR+ in healthy control, pre-treatment and after-treatment group were （78±5）%, （92.3±6.7）%, （81.2±4.6）%. The rate had a significant decrease in after-treatment v.s. pre-treatment (P=0.044), level of IL-4, IL-8, TNF-α and COX2 were also markedly decreased after treatment (P<0.05). Conclusion:Linggui prescription might improve adolescent acne vulgaris through innate immunity regulation. |
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