世界中医药

目的：探讨独一味胶囊联合聚维酮碘治疗牙龈炎的疗效和对炎性反应递质及牙龈状况的影响。方法：选取2015年7月至2017年10月惠州市第六人民医院收治的牙龈炎患者114例，随机分为观察组与对照组，每组57例。对照组采用聚维酮碘治疗，观察组在对照组的基础上加用独一味胶囊治疗，2组治疗周期为15 d。统计2组临床疗效；比较治疗前后2组血清炎性反应递质、牙龈状况及相关生化指标水平。结果：治疗后，观察组的总有效率为91.23%，显著高于对照组的80.70%（P<0.05）；与治疗前比较，治疗后2组患者龈沟液中白细胞介素-1β（IL-1β）、前列腺素E2（PGE2）、C反应蛋白（CRP）及可溶性黏附分子（sICAM-1）水平均显著下降，且观察组显著低于对照组（P<0.05）；与治疗前比较，治疗后2组龈沟出血指数（SBI）、牙龈指数（GI）、牙菌斑指数（PLI）均显著下降（P<0.05），且观察组显著低于对照组（P<0.05）；与治疗前比较，治疗后2组患者血清总胆固醇（TC）及空腹血糖（FPG）水平均显著下降（P<0.05），且观察组显著低于对照组（P<0.05）；2组血清低密度脂蛋白（LDL）、高密度脂蛋白（HDL）水平治疗前后均无显著变化（P>0.05）。结论：独一味胶囊联合聚维酮碘治疗牙龈炎可有效降低龈沟液中炎性反应递质水平，改善患者牙周状况，在调控相关生化指标方面具有积极作用。

English Summary:

To explore the effects of Duyiwei capsule combined with povidone iodine in the treatment of gingivitis on inflammatory factors and gingival condition. Methods:One hundred and fourteen gingivitis cases selected in our hospital from July 2015 to October 2017 were randomly divided into the observation group and the control group, with 57 cases in each group. The control group was treated with povidone iodine while the observation group additionally treated with Duyiwei capsule. The course of both groups was 15 days. The clinical effects of the 2 groups were statistically analyzed, and the levels of serum inflammatory factors, gingival condition and related biochemical indexes of the 2 groups before and after treatment were compared. Results:The total effective rate of the observation group was 91.23%, which was significantly higher than that of the control group (80.70%) (P<0.05). Compared with that of before treatment, the levels of IL-1, PGE2, CRP and sICAM-1 in gingival crevicular fluid of the 2 groups decreased significantly after treatment, and the observation group was significantly lower than that of the control group (P<0.01). Compared with that of before treatment, the SBI, GI and PLI of the 2 groups decreased significantly after treatment (P<0.01), and the observation group was significantly lower than that of the control group (P<0.05 or P<0.01). Compared with those before treatment, the serum TC and FPG levels of the 2 groups decreased significantly after treatment (P<0.01) of which observation group were significantly lower than that of the control group (P<0.05); The serum LDL and HDL levels of the 2 groups had no significant change before and after treatment (P>0.05). Conclusion:Duyiwei capsule combined with povidone iodine in the treatment of gingivitis can effectively reduce the levels of inflammatory factors in gingival crevicular fluid, improve the gingival condition of patients and play a positive role in the regulation of related biochemical indicators.

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