| 引用本文:喻敏，王慧敏，王少飞.射干麻黄汤对咳嗽变异性哮喘的疗效观察及其对免疫平衡的影响[J].世界中医药,2018,(07):. |
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| 射干麻黄汤对咳嗽变异性哮喘的疗效观察及其对免疫平衡的影响 |
| Efficacy Observation on Shegan Mahuang Decoction in the Treatment of Cough Variant Asthma and the Effects on the Immune Balance |
| 投稿时间：2018-01-16 |
| DOI：10.3969/j.issn.1673-7202.2018.07.016 |
| 中文关键词: 咳嗽变异性哮喘 射干麻黄汤 临床疗效 证候评分 肺功能 免疫系统 |
| English Keywords:Cough variant asthma Shegan Mahuang Decoction Clinical efficacy Symptom score Lung function Immune system Pulmonary function Th1/Th2 |
| 基金项目:陕西省科技计划项目（2014K02-11-01) |
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| 中文摘要: |
| 目的：评价射干麻黄汤对咳嗽变异性哮喘的临床疗效，观察其在改善细胞免疫功能的作用，并分析其机制。方法：选取咳嗽变异性哮喘患者60例，随机分为对照组及观察组，每组30例。对照组患者口服孟鲁司特钠（10 mg/次，1次/d）及吸入布地奈德（300 μg/次，2次/d），吸入后漱口，观察组在对照组治疗方案基础上加用射干麻黄汤，200 mL煎煮，早晚分服温服，1剂/d。2组均连续治疗14 d，比较治疗前后2组患者咳嗽症状评分、肺功能、诱导痰中性粒细胞计数以及Th1/Th2比值变化。结果：2组患者治疗后咳嗽症状评分均有下降，观察组下降的幅度大于对照组，差异有统计学意义（P<0.05）；治疗后2组肺功能指标均有改善，其中观察组各指标优于对照组（P<0.05）；2组患者治疗后诱导2组中性粒细胞百分比均减少，观察组优于对照组（P<0.05）；治疗后2组患者Th1/Th2比例均有所上调，观察组提升更明显，差异有统计学意义（P<0.05）。结论：射干麻黄汤可有效治疗咳嗽变异性哮喘，提高人体细胞免疫功能力。 |
| English Summary: |
| To evaluate the curative effect of Shegan Mahuang Decoction on the cough variant asthma, and to observe the effects on improving cellular immune function and analyze the mechanism.Methods:A total of 60 cases of patients with cough variant asthma were included in research, and randomly divided into the control group and the observation group, with 30 cases in each group.The patients in the control group had oral Montelukast (10 mg/times, 1 time/day) and inhaled budesonide (300 μg/time, 2 times/d), rinse the mouth after inhalation.The observation group had Shegan Mahuang Decoction on the basis of treatment of the control group, with 200 mL decoction, warm-taken separately in the morning and evening, 1 agent/day.Both groups had 14 d continuous treatment.The cough symptom scores, pulmonary function, neutrophil count in induced sputum and Th1/ Th2 ratio changes of two groups before and after the treatment were compared.Results:1) Cough symptom scores of the patients in both the two groups decreased after treatment, and the descend range of the observation group was greater than that of the control group.The differences were statistically significant (P<0.05); 2) Pulmonary function index of the two groups improved after treatment, and each index of the observation group was superior to that of the control group (P<0.05); 3) Neutrophil percentage of induced sputum reduced in the patients of the two groups after treatment, and the observation group was superior to that of control group (P<0.05); 4) Proportional of Th1/Th2 increased in the patients of both the two groups after treatment, and the promotion of the observation group was more obvious.The differences were statistically significant (P<0.05).Conclusion:Shegan Mahuang Decoction can effectively treat cough variant asthma, and improve cell-mediated immunity function in the human body. |
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