| 引用本文:石群，王英.连花清瘟胶囊联合利巴韦林雾化吸入治疗小儿呼吸道合胞病毒感染的疗效观察[J].世界中医药,2018,(07):. |
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| 连花清瘟胶囊联合利巴韦林雾化吸入治疗小儿呼吸道合胞病毒感染的疗效观察 |
| Efficacy Observation of Lianhua Qingwen Capsule Combined with Ribavirin Aerosol in the Treatment of Children Respiratory Syncytial Virus Infection |
| 投稿时间：2017-03-15 |
| DOI：10.3969/j.issn.1673-7202.2018.07.026 |
| 中文关键词: 连花清瘟胶囊 利巴韦林 呼吸道合胞病毒感染 雾化吸入 白细胞介素 干扰素 免疫应答 疗效观察 |
| English Keywords:Lianhua Qingwen Capsule Ribavirin aerosol Respiratory syncytial virus infection Atomization inhalation Interleukin Interferon Immune response Efficacy observation |
| 基金项目:重庆市卫生科技计划项目(20111642) |
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| 中文摘要: |
| 目的:观察连花清瘟胶囊联合利巴韦林雾化吸入治疗小儿呼吸道合胞病毒(RAV)感染的临床疗效。方法:选取2016年1月至2016年10月重庆市九龙坡区人民医院收治的呼吸道合胞病毒感染患儿106例作为研究对象,随机分为观察组和对照组,每组53例。对照组患儿给予利巴韦林气雾剂吸入治疗,观察组患儿在对照组基础上口服连花清瘟胶囊,7 d为1个疗程。观察2组患儿退热时间,鼻塞、流涕、咳嗽等症状消失时间,并进行疗效判定。治疗前后,采用电化学发光免疫法检测患儿血清白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-12(IL-12)和干扰素-γ(IFN-γ)的水平。结果:观察组患儿的临床疗效显著优于对照组(Z=2.253,P<0.05)。观察组患儿退热时间,鼻塞、流涕、咳嗽等症状消失时间显著短于对照组(P<0.05)。治疗后,2组患儿血清IL-12和IFN-γ水平均较治疗前升高,且观察组高于对照组(P<0.05);血清IL-4和IL-10水平均较治疗前降低,且观察组低于对照组(P<0.05)。结论:连花清瘟胶囊联合利巴韦林雾化吸入治疗小儿呼吸道合胞病毒感染的疗效确切,在退热和改善鼻塞、流涕、咳嗽等症状方面具有明显优势,且能有效纠正患儿Th1/Th2免疫应答失衡。 |
| English Summary: |
| To observe the clinical efficacy of Lianhua Qingwen capsule combined with ribavirin aerosol in the treatment of children respiratory syncytial virus infection. Methods:A total of 106 children with respiratory syncytial virus infection treated in our hospital from January 2016 to October 2016 were selected as research objects. All of the children were randomly assigned into observation group and the control group, with 53 children in each group. Children in the control group were treated with ribavirin aerosol, while children in the observation group were treated with Lianhua Qingwen capsule on the basis of the control group. The course of treatment was 7 d. The fever annealing time, cough disappearance time, runny nose disappearance time and nasal obstruction disappearance time were observed. The clinical efficacy was judged after treatment. The levels of serum interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-12 (IL-12) and interferon-γ (IFN-γ) were detected by electrochemiluminescence immunoassay. Results:The clinical efficacy of the observation group was significantly better than that of the control group (Z=2.253, P<0.05). The fever annealing time, the cough, runny nose and nasal obstruction disappearance time of the observation group was significantly shorter than that of the control group (P<0.05). After treatment, the serum levels of IL-12 and IFN-γ in 2 groups were higher than those before treatment, and the observation group was higher than that of the control group (P<0.05). The serum levels of IL-4 and IL-10 were lower than that before treatment, and the observation group was lower than that of the control group (P<0.05). Conclusion:Lianhua Qingwen capsule combined with ribavirin aerosol has a definite clinical efficacy in fever annealing and improving cough, runny nose and nasal congestion, and can effectively correct the imbalance of Th1/Th2 immune response in children. |
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