To explore the effects of Yiqi Huashi Recipe combined with western medicine on gastric mucosa in patients with Helicobacter pylori (Hp) infection gastritis.Methods:A total of 118 cases of Hp infected gastritis treated by outpatient department and inpatient department of our hospital were divided into observation group and control group according to the random number table method，with 59 cases in each group.Control group was treated with routine western medicine，and observation group was treated with Yiqi Huashi Recipe on the basis of control group.Both groups were treated for 1 month continuously.The clinical curative effect and Hp clearance effect of 2 groups were counted and compared before and after treatment; The traditional Chinese medicine (TCM) syndrome scores and gastric mucosal status in 2 groups before and after treatment were statisticed and compared.Results:After treatment，the total effective rate and Hp negative conversion rate in observation group were 91.53% and 88.14% respectively，which were significantly higher than the 77.97%，69.49% in control group (P<0.05).Compared with before treatment，the scores of TCM symptoms such as stomachache，anorexia，fatigue，loose stool，unwarm limbs in 2 groups after treatment significantly decreased (P<0.01).The observation group was significantly lower than control group (P<0.05 or P<0.01).Compared with before treatment，the infiltration of inflammatory cells，density of gland，thickness of mucosa and gland morphology scores decreased significantly in 2 group after treatment significantly decreased (P<0.01)，and observation group was significantly lower than control group (P<0.05 or P<0.01).Conclusion:Yiqi Huashi Recipe combined with western medicine to treat Hp infectious gastritis significantly alleviates the clinical symptoms，improves the gastric mucosal condition，and promotes the Hp clearance effect，which is worthy of clinical promotion.