世界中医药
文章摘要
引用本文:彭艳芳1,岳莹莹1,张莹雯2,艾望3,赵映前1.芪归方联合泼尼松治疗特发性肺纤维化的临床研究[J].世界中医药,2018,(08):.  
芪归方联合泼尼松治疗特发性肺纤维化的临床研究
Clinical Study on the Treatment of Idiopathic Pulmonary Fibrosis Treated with Qigui Recipe Combined with Prednisone
投稿时间:2018-05-02  
DOI:10.3969/j.issn.1673-7202.2018.08.022
中文关键词:  特发性肺纤维化  芪归方  临床疗效  不良反应  中医证候积分  6 min步行距离  炎性因子  生命质量
English Keywords:Idiopathic pulmonary fibrosis  Qigui recipe  Clinical efficacy  Adverse reactions  TCM syndrome score  Six minute walking distance  Inflammatory factors  Quality of life
基金项目:国家自然科学基金面上项目(30973705)
作者单位
彭艳芳1,岳莹莹1,张莹雯2,艾望3,赵映前1 1 湖北中医药大学武汉430065 2 武汉大学中南医院武汉430071 3 武汉大学武汉430071 
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中文摘要:
      目的:探讨芪归方联合泼尼松治疗特发性肺纤维化的临床疗效及对炎性因子水平的影响。方法:选取2016年10月至2018年2月武汉大学中南医院收治的特发性肺纤维化患者50例,并随机分为观察组和对照组,每组25例。对照组采用常规治疗方法,观察组在对照组的基础上加用芪归方,2组均连续治疗12周。评价2组患者临床疗效和泼尼松不良反应的影响,观察中医证候积分、6 min步行距离、生命质量评分,应用酶联免疫法检测血清肿瘤坏死因子α(TNF-α)和转化生长因子-β1(TGF-β1)等炎性因子水平。结果:观察组总有效率为84%,显著高于对照组的76%(P<0.05);治疗后2组中医证候积分、生命质量积分、TNF-α和TGF-β1均较治疗前显著下降(P<0.01),且观察组优于对照组(P<0.05或P<0.01);治疗后2组6 min步行距离较治疗前显著上升(P<0.01),组间比较差异有统计学意义(P<0.05或P<0.01)。结论:芪归方联合泼尼松治疗特发性肺纤维化可有效降低患者体内炎性因子水平,改善患者的中医证候,提高运动耐力和生命质量。
English Summary:
      To explore the curative effect of Qigui recipe combined with prednisone in the treatment of patients with idiopathic pulmonary fibrosis.Methods:A total of 50 cases of patients with idiopathic pulmonary fibrosis in our hospital were selected and randomly divided into the treatment group (n=25) and the control group (n=25).The control group was treated with prednisone,and treatment group was treated with Qigui recipe combined with prednisone.And the following items in the two groups were recorded before and after the treatment:the TCM syndrome score,adverse reaction,six minute walking distance and quality of life score,as well as serum levels of TNF-α and TGF-β1 were detected by enzyme linked immunosorbent assay (Elisa).Results:The total effective rate of the observation group was 84%,which was significantly higher than 76% of the control group (P<0.05).After treatment,the TCM syndrome scores,quality of life scores,TNF-α and TGF-β1 of the two groups were significantly lower than before treatment.The observation group was superior to the control group (P<0.05 or P<0.01).The 6-minute walking distance of the two groups was significantly increased than that before the treatment (P<0.01),and the difference between the groups was statistically significant (P<0.05 or P<0.01).Conclusion:The combination of Qigui recipe and prednisone is effective in the treatment of idiopathic pulmonary fibrosis patients.It better improved the patient's TCM syndrome,improved exercise endurance and quality of life,adjusted the level of inflammatory factors,improved clinical symptoms.
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