To explore the influence of mirena combined with Sanjie Zhentong capsule on the uterine volume，dysmenorrhea and menstruation of patients with adenomyosis.Methods:A total of 78 patients with adenomyosis in Zhongshan Torch Development Zone Hospital from November 2015 to January 2017 were selected and randomly divided into observation group and control group，with 39 cases in each group.Patients of control group were placed mirena in the uterine cavity，and patients in observation group were treated with oral Sanjie Zhentong capsule on the basis of the treatment in control group.Both groups were treated for 6 months.The clinical efficacies of the 2 groups were compared.The uterine volume，dysmenorrhea and menstruation of the 2 groups were compared before and after treatment，and the adverse reactions of 2 groups were recorded.Results:The total effective rate of observation group was 87.18%，which was obviously higher than 66.67% in control group (P<0.05).Compared with before the treatment，the uterine volume levels of 2 groups were decreased obviously in the 1st，3rd，6th month after treatment.The scores of VAS，PBAC and serum CA125 were decreased significantly in the 2 groups (P<0.05).The uterine volume of observation group was significantly less than that of the control group at each time point after the treatment.The scores of VAS，PBAC and serum CA125 of observation group were significantly lower than that in control group at each time point after the treatment (P<0.05).The total rate of adverse reactions in the observation group (15.38%) was significantly lower than that in the control group (30.77%) (P<0.05).Conclusion:Mirena combined with Sanjie Zhentong capsule can significantly contract the uterine volume，improve dysmenorrhea and menstrual volume in the treatment of adenomyosis，and the safety is better.It is worthy of clinical application.