To observe the effects of five elements in music (jue tone) of Traditional Chinese Medicine on macroscopic characterization and irritability of hypertensive rats with liver-fire hyperactivity.Methods:A total of 20 spontaneously hypertensive rats (SHR) were randomly divided into jue tone (experimental) group and control group,with 10 rats in each group.The experimental group was given jue tone intervention for 4 weeks,and control group was not treated.Weekly dynamic macro indicators were collected,and the macroscopic characterization before and after the intervention were observed.The irritability was compared and evaluated.Results:After 4 weeks' intervention by jue tone,compared with control group,the general status and tail score of rats in experimental group were significantly higher,and there was significant differences between the 2 groups (P<0.05).There was significant difference in evaluation of irritability between experimental group and control group.Conclusion:Jue tone has significant effects on the macroscopic characterization and evaluation of irritability of SHR rats with liver-hypertension syndrome.