To explore the clinical efficacy of Shenqi Fuzheng Injection combined with chemotherapy on hematological malignancy and the effects on hematopoiesis and immune function in patients.Methods:A total of 113 patients with hematological malignancy treated in Department of Oncology of Fifth People's Hospital of Wuxi City from July 2015 to February 2017 were selected and divided into control group and observation group according to the random number table method,with 56 cases in control group and 57 cases in observation group.Both groups were treated with conventional chemotherapy methods,and the observation group was additionally given Shenqi Fuzheng Injection on the basis of this group for 2 month.The clinical efficacy of both groups was statistically analyzed,and the changes of hematopoiesis function,T lymphocyte immune and RBC immune function indexes were detected and compared.Results:The remission rate of observation group was 91.23%,which was higher than 76.79% of control group (P<0.05).Compared with before treatment,the peripheral blood WBC of both groups decreased significantly after treatment (P<0.05),and the RBC,PLT and Hb contents increased significantly after treatment (P<0.05 or P<0.01),and the difference between the two groups was statistically significant (P<0.01).Compared with before treatment,the proportions of CD4+ T lymphocyte and CD4+/CD8+ of both groups were decreased significantly,but observation group decreased more than control group (P<0.01),and the proportion of CD8+ T lymphocyte of control group increased while observation group decreased,but the difference was not significant (P>0.05),and the proportion of CD8+ T lymphocyte of observation group was lower than control group (P<0.01).Compared with before treatment,the RBC-C3bRR and TRR of observation group significantly were increased after treatment (P<0.01) but the RBC-ICR was decreased significantly,and the difference of 2 groups was significant (P<0.01).Conclusion:Shenqi Fuzheng Injection can effectively protect the hematopoiesis and immune function of patients with hematological malignancy effectively,and increase the clinical efficacy significantly.