To explore the effects of adjuvant therapy with Danji Huoxue Decoction on liver function and serum inflammatory factors in patients with chronic hepatitis B liver fibrosis.Methods:A total of 160 patients with chronic hepatitis B liver fibrosis treated in Handan Hospital of Infectious Disease from March 2015 to March 2017 were selected and randomly divided into observation group and control group,with 80 cases in each group.Control group was treated with routine liver protection while observation group was treated with Danji Huoxue Decoction on the basis of the same treatment.Both groups were continuously treated for 2 courses (3 months as a course).The changes of Traditional Chinese Medicine (TCM) syndromes scores,liver function index,liver fibrosis index and serum inflammatory factor level in both groups were compared before and after treatment.Results:Compared with before treatment,the scores of major TCM syndromes such as liver discomfort or pain,dark red tongue,dark complexion,loss of appetite and fatigue of both groups were significantly decreased after treatment (P<0.01),and observation group decreased more significantly than control group (P<0.05 or P<0.01).Compared with before treatment,the serum ALT,TBILN,AST levels decreased significantly in both groups after treatment (P<0.01),and the levels of observation group decreased more significantly than control group (P<0.05 or P<0.01).ALB levels increased significantly (P<0.01),and observation group increased more significantly than control group (P<0.05 or P<0.01).Compared with before treatment,the serum HA,LN,PC-Ⅲ,Ⅳ-C,MMP-1,IL-6,TNF-α of both groups and the MDA level of observation group were significantly decreased (P<0.05 or P<0.01),and the levels of MDA in the observation group significantly decreased after treatment.The observation group decreased more significantly than control group (P<0.05 or P<0.01).Conclusion:The adjuvant therapy with Danji Huoxue Decoction in the treatment of chronic hepatitis B liver fibrosis can effectively improve the clinical symptoms,improve the liver function and inhibit the progress of liver fibrosis.Its mechanism may be related to the reduction of inflammatory factors level.