To investigate the effects of Yangxinshi tablet on cardiac function and plasma levels of brain natriuretic peptide (BNP) of patients with chronic heart disease.Methods:A total of 60 patients with congestive heart failure (CHF) treated in Internal Medicine Department in Mianyang Hospital of Traditional Chinese Medicine from October,2014 to October,2017 were selected and divided into control group and observation group according to the random-number table method,with 30 patients in each group.Based on conventional treatment,the observation group was given Yangxinshi Tablet,while the control group was only given conventional treatment.The data of 6-minute walking distance test and cardiac color ultrasound,the levels of plasma BNP,total clinical efficiency in both groups of patients before and after treatment were compared and analyzed.Results:Compared before treatment,the level of plasma BNP in both groups improved,and improvement of the observation group was better than the control group.The difference was statistically significant (P<0.05).The total clinical efficiency of observation group (93.33%) was significantly higher than the control group (73.33%).The difference was statistically significant (P<0.05).Conclusion:Yangxinshi Tablet can effectively improve patients' heart function,lengthen the distance of 6-min walking test and significantly reduce the plasma BNP levels.It has obvious therapeutic effects on patients with chronic heart failure.And it is worth promoting and applying in clinical practice.