To investigate the effect of Bushen Huoxue decoction on the level of IGF-1, hs-CRP and blood rheology in patients with deficiencies of qi and yin and blood stasis type of diabetic nephropathy. Methods:The clinical date of 90 cases of patients with deficiencies of qi and yin and blood stasis type of diabetic nephropathy were retrospectively analyzed during May 2015 to September 2016, and according to treatment method, they were divided into control group and research group. All patients were given hypoglycemic, control of blood pressure and blood fat, anti-inflammatory and other conventional treatment. On the basis of conventional treatment, the control group were given oral boehner simplex, and research group were given Bushen Huoxue decoction on the basis of control group. After treatment of 12 weeks, the curative effect of two groups was observed before and after treatment. Fasting blood glucose, postprandial blood glucose, glycosylated serum protein, IGF-1, hs-CRP and blood rheology indexes were compared. Results:1)After treatment, total effective rate of research group was 88.37%; total effective rate of control group was 69.77%; with significant difference (χ2=10.024, P=0.007＜0.05); 2)FBG, PBG, UAER and GSP after treatment in two groups was decreased, and the difference was statistically significant (P<0.05). And FBG, PBG, UAER and GSP after treatment in research group were lower than control group, with statistically significant difference (P<0.05); 3)After treatment, IGF-1, hs-CRP in two groups was decreased with statistically significant difference (P<0.05), and IGF-1, hs-CRP after treatment in research group were more lower than control group with statistical significance (P<0.05); 4)There was no obvious difference for blood rheology indexes in control group between after treatment and before treatment (P>0.05), and hemorheology indexes after treatment in research group was reduced. The difference was statistically significant (P<0.05); hemorheology index after treatment in research group was lower than control group with statistically significant difference (P<0.05). Conclusion:The effect of Bushen Huoxue decoction in treatment of patients with deficiency of qi and yin and blood stasis type of diabetic nephropathy is significant, which can significantly reduce the blood sugar and serum IGF-1, hs-CRP, as well as improve blood rheology.