To evaluate the clinical effects of Modified Longdan Xiegan Decoction on chronic pelvic inflammatory disease with damp-heat accumulation and to observe the changes of inflammatory factors concentration.Methods:A total of 60 patients with chronic pelvic inflammatory disease with damp-heat accumulation treated in Traditional Chinese Medicine Hospital of Lu'an from January 2017 to December 2017 were selected and randomly divided into the control group and the observation group,with 30 cases in each group.The control group received conventional treatment.Based on the same conventional treatment of the control group,the observation group was given Longdan Xiegan Decoction one dose a day continuously treated for 7 days.Before and after treatment,the scores of TCM syndromes,clinical efficacy,cervical or vaginal mucous purulent secretions,white blood cells,the total number of white blood cells,the changes of absolute value of neutrophils and IL-6,IL-8 and TNF-ɑ concentrations in the peripheral blood in both groups were compared.Results:The scores of TCM syndromes in both groups decreased after treatment (P<0.05),and the scores in the observation group after treatment were lower than those in the control group (P<0.05).After treatment,the total clinical effective rate of the observation group was 92.5%,and compared with the control group (72.5%),the difference was statistically significant (χ2=2.38,P<0.05).After treatment,the cervical or vaginal mucous purulent secretions,the white blood cells,the total number of white blood cells and the absolute neutrophils of the vaginal secretions all decreased after the treatment (P<0.05),and the number of observation group decreased more than control group (P<0.05).The concentrations of serum IL-6,IL-8 and TNF-ɑ decreased in both groups after treatment,and the difference was statistically significant (P<0.05).The decrease of the observation group was more than that of the control group (P<0.05).Conclusion:Longdan Xiegan Decoction has an ideal curative effect on chronic pelvic inflammatory disease with damp-heat accumulation,and its mechanism is related to the inhibition of the expression of IL-6,IL-8 and TNF-ɑ.