| 引用本文:袁蕾，王翠翠，苏凯凯.龙胆泻肝汤加减对湿热蕴结型慢性盆腔炎的疗效及对炎性反应因子的影响[J].世界中医药,2018,(09):. |
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| 龙胆泻肝汤加减对湿热蕴结型慢性盆腔炎的疗效及对炎性反应因子的影响 |
| Efficacy of Modified Longdan Xiegan Decoction on Chronic Pelvic Inflammatory Disease with Damp-heat Accumulation and Effects on Serum Inflammatory Factors |
| 投稿时间：2018-05-29 |
| DOI：10.3969/j.issn.1673-7202.2018.09.014 |
| 中文关键词: 慢性盆腔炎 湿热蕴结型 龙胆泻肝汤 IL-6 IL-8 TNF-ɑ |
| English Keywords:Chronic pelvic Damp-heat accumulation Longdan Xiegan Decoction IL-6 IL-8 TNF-ɑ |
| 基金项目:安徽省高校自然科学研究项目（kj20078329zc） |
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| 中文摘要: |
| 目的：评价龙胆泻肝汤加减对湿热蕴结型慢性盆腔炎的临床疗效，并观察其对炎性反应因子浓度的影响。方法：选取2017年1月至2017年12月安徽省六安市中医院收治的湿热蕴结型慢性盆腔炎患者60例，随机分为对照组和观察组，每组30例。对照组接受西医常规治疗，观察组在对照组常规治疗基础上加用龙胆泻肝汤加减，1剂/d，连续治疗7 d。比较2组患者治疗前后中医证候积分，临床疗效，宫颈或阴道黏液脓性分泌物，阴道分泌物湿片镜下白细胞、白细胞总数、中性粒细胞绝对值变化，以及外周血IL-6、IL-8、TNF-ɑ因子的浓度变化。结果：2组患者治疗后中医证候积分较治疗前减少（P<0.05），治疗后观察组积分较对照组低（P<0.05）。治疗后观察组临床总有效率为92.5%，与对照组的72.5%比较，差异有统计学意义（χ2=2.38，P<0.05）。治疗后2组患者宫颈或阴道黏液脓性分泌物以及阴道分泌物湿片镜下白细胞、白细胞总数、中性粒细胞绝对值均较治疗前下降（P<0.05），观察组优于对照组（P<0.05）。2组治疗后外周血清IL-6、IL-8、TNF-ɑ因子浓度有所下降，与治疗前比较，差异有统计学意义（P<0.05），观察组下降幅度大于对照组（P<0.05）。结论：龙胆泻肝汤加减对湿热蕴结型慢性盆腔炎有理想的疗效，其作用机制可能与抑制IL-6、IL-8、TNF-ɑ表达有关。 |
| English Summary: |
| To evaluate the clinical effects of Modified Longdan Xiegan Decoction on chronic pelvic inflammatory disease with damp-heat accumulation and to observe the changes of inflammatory factors concentration.Methods:A total of 60 patients with chronic pelvic inflammatory disease with damp-heat accumulation treated in Traditional Chinese Medicine Hospital of Lu'an from January 2017 to December 2017 were selected and randomly divided into the control group and the observation group,with 30 cases in each group.The control group received conventional treatment.Based on the same conventional treatment of the control group,the observation group was given Longdan Xiegan Decoction one dose a day continuously treated for 7 days.Before and after treatment,the scores of TCM syndromes,clinical efficacy,cervical or vaginal mucous purulent secretions,white blood cells,the total number of white blood cells,the changes of absolute value of neutrophils and IL-6,IL-8 and TNF-ɑ concentrations in the peripheral blood in both groups were compared.Results:The scores of TCM syndromes in both groups decreased after treatment (P<0.05),and the scores in the observation group after treatment were lower than those in the control group (P<0.05).After treatment,the total clinical effective rate of the observation group was 92.5%,and compared with the control group (72.5%),the difference was statistically significant (χ2=2.38,P<0.05).After treatment,the cervical or vaginal mucous purulent secretions,the white blood cells,the total number of white blood cells and the absolute neutrophils of the vaginal secretions all decreased after the treatment (P<0.05),and the number of observation group decreased more than control group (P<0.05).The concentrations of serum IL-6,IL-8 and TNF-ɑ decreased in both groups after treatment,and the difference was statistically significant (P<0.05).The decrease of the observation group was more than that of the control group (P<0.05).Conclusion:Longdan Xiegan Decoction has an ideal curative effect on chronic pelvic inflammatory disease with damp-heat accumulation,and its mechanism is related to the inhibition of the expression of IL-6,IL-8 and TNF-ɑ. |
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