| To observe the clinical effect of tripterygium wilfordii glycosides tablets combined with compound ganoderma kidney invigorating method in the treatment of early diabetic nephropathy (DN) and the influences on the level of serum inflammatory factors, renal function and the vascular endothelial function.Methods:A total of 126 cases of early DN in our hospital from April 2015 to December 2016 were selected as research subjects, and divided into the observation group and the control group according to random number table, with 63 cases in each group.The control group was given the basic treatment and tripterygium glycosides tablets, while the observation group was given compound ganoderma kidney invigorating method based on the treatment of the control group.Two groups were treated for 3 months.The clinical curative effect, the level of serum inflammatory factors (TNF-α, IL-6, IL-18), the renal function (SCr, BUN, UREA), the vascular endothelial function (ET-1, MDA, NO, SOD, VEGF) of two groups were observed.Results:The levels of SCr, BUN, UREA, TNF-α, IL-6, IL-18, ET-1, MDA were decreased, and the levels of NO, SOD, VEGF were increased markedly of two groups (P<0.05).The above indexes of the observation group were changed more obviously than the control group.The differences were statistically significant (P<0.05).The total effective rate of the observation group was 92.06%, while the total effective rate of the control group was 77.78%.The difference was statistically significant (P<0.05).Conclusion:Tripterygium wilfordii glycosides tablets combined with compound ganoderma kidney invigorating method can improve the vascular endothelial function and the renal function, reduce the level of serum inflammatory factors, resist oxidative stress, and improve the clinical effect of early diabetic nephropathy. |
