To observe the clinical efficacy of Shenfu injection in the treatment of acute internal watershed cerebral infarction.Methods:A total of 80 patients with acute internal watershed cerebral infarction admitted to Dongzhimen Hospital from December 2014 to December 2016 were randomly divided into observation group and control group, with 40 cases in each group.Both groups were given antiplatelet aggregation, blood lipid reduction, blood pressure regulation, blood volume, microcirculation, and protection of brain cells.The observation group added Shenfu injection on the basis of this, 100 mL/day, infusion pump, 20 mL/h for 14 days.Before and after treatment, the National Institutes of Health Stroke Scale (NIHSS) was used to score neurological deficits.TCD was used to measure the blood flow velocity of the middle cerebral artery of the diseased side of both groups.Results:Compared with before treatment, the blood flow velocity of the middle cerebral artery was increased in both groups after treatment, and was significant in the observation group (P<0.05).NIHSS scores were lower than before treatment in this group.NIHSS scores in the observation group after treatment were significantly lower than those in the control group (P<0.05).Conclusion:Shenfu injection can obviously improve the blood flow velocity and prognosis of the distally-responsive artery in the internal watershed cerebral infarction caused by middle cerebral artery stenosis.