| 引用本文:张宇1，郭楠2，孔令博2，姜尚上2，张华1，杨保林1.参附注射液在治疗内分水岭脑梗死患者的临床疗效[J].世界中医药,2018,(09):. |
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| 参附注射液在治疗内分水岭脑梗死患者的临床疗效 |
| Clinical Observation on Shenfu Injection in Watershed Cerebral Infarction |
| 投稿时间：2017-07-31 |
| DOI：10.3969/j.issn.1673-7202.2018.09.017 |
| 中文关键词: 大脑中动脉狭窄 内分水岭脑梗死 参附注射液 经颅多普勒 神经功能缺损评分，临床疗效观察，血流速度，低灌注 |
| English Keywords:Middle cerebral artery stenosis Internal watershed cerebral infarction Shenfu injection TCD Neurological deficit score Clinical efficacy observation Blood flow velocity Hypoperfusion |
| 基金项目:国家中医药管理局中医药科学技术研究专项课题（2013-BAI13B02）；北京中医药新奥奖励基金课题(2017-XAJLJJ-015) |
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| 中文摘要: |
| 目的：观察参附注射液治疗急性内分水岭脑梗死患者的临床疗效。方法：选取2014年12月至2016年12月东直门医院神经内科收治的急性内分水岭脑梗死患者80例，完全随机分为观察组和对照组，每组40例。2组均给予抗血小板聚集、降血脂、调控血压、补充血容量、改善微循环和保护脑细胞等治疗。观察组在此基础上加用参附注射液，100 mL/d，输液泵泵入，20 mL/h，共14 d。治疗前后应用美国国立卫生研究院卒中量表（NIHSS）进行神经功能缺损评分，通过经颅多普勒（TCD）检测2组病变侧大脑中动脉血流速度。结果：与治疗前比较，2组患者治疗后大脑中动脉血流速度均有提高，观察组优于对照组，差异有统计学意义（P<0.05）。2组NIHSS评分均低于本组治疗前，观察组治疗后NIHSS评分明显低于对照组，差异有统计学意义（P<0.05）。结论：参附注射液治疗可明显改善大脑中动脉狭窄所致内分水岭脑梗死责任动脉远端的血流速度及患者预后。 |
| English Summary: |
| To observe the clinical efficacy of Shenfu injection in the treatment of acute internal watershed cerebral infarction.Methods:A total of 80 patients with acute internal watershed cerebral infarction admitted to Dongzhimen Hospital from December 2014 to December 2016 were randomly divided into observation group and control group, with 40 cases in each group.Both groups were given antiplatelet aggregation, blood lipid reduction, blood pressure regulation, blood volume, microcirculation, and protection of brain cells.The observation group added Shenfu injection on the basis of this, 100 mL/day, infusion pump, 20 mL/h for 14 days.Before and after treatment, the National Institutes of Health Stroke Scale (NIHSS) was used to score neurological deficits.TCD was used to measure the blood flow velocity of the middle cerebral artery of the diseased side of both groups.Results:Compared with before treatment, the blood flow velocity of the middle cerebral artery was increased in both groups after treatment, and was significant in the observation group (P<0.05).NIHSS scores were lower than before treatment in this group.NIHSS scores in the observation group after treatment were significantly lower than those in the control group (P<0.05).Conclusion:Shenfu injection can obviously improve the blood flow velocity and prognosis of the distally-responsive artery in the internal watershed cerebral infarction caused by middle cerebral artery stenosis. |
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